A. Kebriaeezadeh, A. Zarghi, R. Ahmadkhaniha, A. Khoddam, A. Ebrahimian
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Simultaneous High‐Performance Liquid Chromatographic Determination of Sulphamethoxazole and Trimethoprim in the Plasma of Man
An HPLC method has been developed for simultaneous analysis of sulphamethoxazole (SMZ) and trimethoprim (TMP) in plasma from man. The detection limits for TMP and SMZ in plasma were 5 and 10ng mL−1, respectively. The average recovery for both compounds was 96% (approx.). The inter- and intra-day coefficients of variation of the assay were found to be less than 8%.
The method is simple, sensitive and suitable for pharmacokinetic studies of sulphamethoxazole and trimethoprim.
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