同种异体反应性组织驻留T细胞造成损伤:内部工作

R. V. van Lier, P. Hombrink
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引用次数: 0

摘要

Snyder等人利用单细胞RNA和TCR测序表明,在急性细胞排斥反应期间,细胞毒性受体来源的组织驻留记忆T细胞存在同种异体移植物特异性克隆扩增,这些细胞毒性受体来源的组织驻留记忆T细胞被重新编程,尽管高剂量糖皮质激素治疗,但仍持续存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Allo-reactive tissue-resident T cells causing damage: An inside job
Using single-cell RNA and TCR sequencing, Snyder et al. show that during acute cellular rejection there is an allograft-specific clonal expansion of cytotoxic recipient-derived tissue resident memory T cells that are reprogrammed but persist despite high-dose glucocorticoid therapy.
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