血小板活化因子受体在GtoPdb v.2023.1中的表达

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI:10.2218/gtopdb/f55/2023.1

R. Hills, S. Ishii, S. Jancar, T. McIntyre, E. Ninio, Chris O'Neill, Francisco Jose Oliveira Rios, J. Travers, M. Whittaker

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引用次数: 0

摘要

血小板活化因子(PAF, 1- o-烷基-2-乙酰- asn -甘油-3-磷酸胆碱)是一种与血小板凝固相关的醚磷脂介质，但也具有炎症作用。PAF受体(NC-IUPHAR[38]推荐的临时命名)被PAF激活，其他建议的内源性配体是氧化磷脂酰胆碱[74]和溶血磷脂酰胆碱[98]。它也可能被细菌脂多糖激活[91]。

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Platelet-activating factor receptor in GtoPdb v.2023.1

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is an ether phospholipid mediator associated with platelet coagulation, but also subserves inflammatory roles. The PAF receptor (provisional nomenclature recommended by NC-IUPHAR [38]) is activated by PAF and other suggested endogenous ligands are oxidized phosphatidylcholine [74] and lysophosphatidylcholine [98]. It may also be activated by bacterial lipopolysaccharide [91].

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IUPHAR/BPS Guide to Pharmacology CITE

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