I. Akase, P. Akintan, E. Otrofanowei, O. Olopade, G. Olorunfemi, A. Opawoye, F. Alakaloko, U. Ima-Edomwonyi, Y. Akinbolagbe, O. Agabi, Danladi Nmadu, G. Akinbode, A. Olasope, A. Ogundare, A. Bolarinwa, Oluwakemi Awojumobi-Otokiti, P. Enajeroh, M. Karami, C. Esezobor, Y. Oshodi, Oluwole Ayotunde, W. Adeyemo, C. Bode
{"title":"尼日利亚拉各斯一家三级医院第一波和第二波COVID-19大流行期间入院患者的临床特征和结果","authors":"I. Akase, P. Akintan, E. Otrofanowei, O. Olopade, G. Olorunfemi, A. Opawoye, F. Alakaloko, U. Ima-Edomwonyi, Y. Akinbolagbe, O. Agabi, Danladi Nmadu, G. Akinbode, A. Olasope, A. Ogundare, A. Bolarinwa, Oluwakemi Awojumobi-Otokiti, P. Enajeroh, M. Karami, C. Esezobor, Y. Oshodi, Oluwole Ayotunde, W. Adeyemo, C. Bode","doi":"10.4103/jcls.jcls_57_22","DOIUrl":null,"url":null,"abstract":"Introduction: Clinical data on the differences in presentation and outcome of admitted COVID-19 patients in Nigeria are limited. This study aimed to compare the first and second waves of the COVID-19 pandemic in a Tertiary Hospital in Lagos and describe the clinical differences between the waves, the severity of COVID-19, and the mortality differences. Methods: The study was a retrospective review of the medical records of all children and adults admitted to the Lagos University Teaching Hospital (LUTH) COVID-19 Isolation and Treatment Centre during the first wave (from April 2020 to October 2020) and second wave (from December 2020 to April 2021). The clinical characteristics (including COVID severity) and outcome among admitted patients during the two waves were compared. Results: Between April 2020 and April 2021, 602 patients were admitted to LUTH for COVID-19. Patients in the first wave were significantly younger (43 vs. 54.5 years), more in number (53.8% vs. 46.2%), and had a higher proportion of health-care workers than those in the second wave (14.5% vs. 6.5%). Comorbidities were present in more than half of the patients hospitalized for COVID-19 infection (51.0%). This proportion was much higher during the pandemic's second wave (41.7% vs. 61.9%, P < 0.001). The most common comorbidity found in hospitalized patients was hypertension (37.0%). Patients admitted during the second wave had shorter stays (11 vs. 7 days) and similar mortality rates (10.2% vs. 10.8%). Conclusion: The first and second waves had comparable mortality rates though patients in the first wave were younger and there were more healthcare providers in the cohort. Patients admitted to the second wave however had more comorbidities but shorter lengths of stay which may suggest a better understanding of the infection and better outcome.","PeriodicalId":15490,"journal":{"name":"Journal of Clinical Sciences","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria\",\"authors\":\"I. Akase, P. Akintan, E. Otrofanowei, O. Olopade, G. Olorunfemi, A. Opawoye, F. Alakaloko, U. Ima-Edomwonyi, Y. Akinbolagbe, O. Agabi, Danladi Nmadu, G. Akinbode, A. Olasope, A. Ogundare, A. Bolarinwa, Oluwakemi Awojumobi-Otokiti, P. Enajeroh, M. Karami, C. Esezobor, Y. Oshodi, Oluwole Ayotunde, W. Adeyemo, C. Bode\",\"doi\":\"10.4103/jcls.jcls_57_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Clinical data on the differences in presentation and outcome of admitted COVID-19 patients in Nigeria are limited. This study aimed to compare the first and second waves of the COVID-19 pandemic in a Tertiary Hospital in Lagos and describe the clinical differences between the waves, the severity of COVID-19, and the mortality differences. Methods: The study was a retrospective review of the medical records of all children and adults admitted to the Lagos University Teaching Hospital (LUTH) COVID-19 Isolation and Treatment Centre during the first wave (from April 2020 to October 2020) and second wave (from December 2020 to April 2021). The clinical characteristics (including COVID severity) and outcome among admitted patients during the two waves were compared. Results: Between April 2020 and April 2021, 602 patients were admitted to LUTH for COVID-19. Patients in the first wave were significantly younger (43 vs. 54.5 years), more in number (53.8% vs. 46.2%), and had a higher proportion of health-care workers than those in the second wave (14.5% vs. 6.5%). Comorbidities were present in more than half of the patients hospitalized for COVID-19 infection (51.0%). This proportion was much higher during the pandemic's second wave (41.7% vs. 61.9%, P < 0.001). The most common comorbidity found in hospitalized patients was hypertension (37.0%). Patients admitted during the second wave had shorter stays (11 vs. 7 days) and similar mortality rates (10.2% vs. 10.8%). Conclusion: The first and second waves had comparable mortality rates though patients in the first wave were younger and there were more healthcare providers in the cohort. Patients admitted to the second wave however had more comorbidities but shorter lengths of stay which may suggest a better understanding of the infection and better outcome.\",\"PeriodicalId\":15490,\"journal\":{\"name\":\"Journal of Clinical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jcls.jcls_57_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jcls.jcls_57_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
简介:关于尼日利亚入院的COVID-19患者的表现和结局差异的临床数据有限。本研究旨在比较拉各斯一家三级医院的第一波和第二波COVID-19大流行,并描述两波之间的临床差异、COVID-19的严重程度和死亡率差异。方法:本研究回顾性分析了第一波(2020年4月至2020年10月)和第二波(2020年12月至2021年4月)期间拉各斯大学教学医院(LUTH) COVID-19隔离和治疗中心收治的所有儿童和成人的医疗记录。比较两波入院患者的临床特征(包括病情严重程度)和转归。结果:2020年4月至2021年4月,602例患者因COVID-19入住LUTH。第一波患者明显更年轻(43岁vs. 54.5岁),数量更多(53.8% vs. 46.2%),并且卫生保健工作者的比例高于第二波患者(14.5% vs. 6.5%)。超过一半的COVID-19感染住院患者存在合并症(51.0%)。这一比例在第二波大流行期间要高得多(41.7%对61.9%,P < 0.001)。住院患者中最常见的合并症是高血压(37.0%)。第二波入院的患者住院时间较短(11天vs. 7天),死亡率相似(10.2% vs. 10.8%)。结论:第一波和第二波的死亡率相当,尽管第一波的患者更年轻,队列中有更多的医疗保健提供者。然而,第二波入院的患者有更多的合并症,但住院时间较短,这可能表明对感染有更好的了解,结果也更好。
Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria
Introduction: Clinical data on the differences in presentation and outcome of admitted COVID-19 patients in Nigeria are limited. This study aimed to compare the first and second waves of the COVID-19 pandemic in a Tertiary Hospital in Lagos and describe the clinical differences between the waves, the severity of COVID-19, and the mortality differences. Methods: The study was a retrospective review of the medical records of all children and adults admitted to the Lagos University Teaching Hospital (LUTH) COVID-19 Isolation and Treatment Centre during the first wave (from April 2020 to October 2020) and second wave (from December 2020 to April 2021). The clinical characteristics (including COVID severity) and outcome among admitted patients during the two waves were compared. Results: Between April 2020 and April 2021, 602 patients were admitted to LUTH for COVID-19. Patients in the first wave were significantly younger (43 vs. 54.5 years), more in number (53.8% vs. 46.2%), and had a higher proportion of health-care workers than those in the second wave (14.5% vs. 6.5%). Comorbidities were present in more than half of the patients hospitalized for COVID-19 infection (51.0%). This proportion was much higher during the pandemic's second wave (41.7% vs. 61.9%, P < 0.001). The most common comorbidity found in hospitalized patients was hypertension (37.0%). Patients admitted during the second wave had shorter stays (11 vs. 7 days) and similar mortality rates (10.2% vs. 10.8%). Conclusion: The first and second waves had comparable mortality rates though patients in the first wave were younger and there were more healthcare providers in the cohort. Patients admitted to the second wave however had more comorbidities but shorter lengths of stay which may suggest a better understanding of the infection and better outcome.