短链脂肪酸和氨基硫醇水平在俄罗斯EMERCOM应对人员与循环系统疾病危险因素的诊断意义

Q3 Health Professions
I. Shantyr, G. G. Rodionov, S. Dudarenko, M. Sannikov, E. V. Svetkina, E. A. Kolobova, O. A. Ezhova, E. S. Saryan
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Therefore, it is relevant to identify the predisposition to CSD as soon as possible in order to maintain good health and longevity among highly qualified professionals of the Ministry of Emergency Situations of Russia.The pathophysiological mechanism underlying progression of atherosclerosis affects complicated interactions between vasculature, immune system and lipid metabolism. Evidence shows that intestinal microbiome exacerbates all compound risk factors for atherosclerosis, both directly and indirectly, thus playing an important role in CSD development.Numerous studies revealed that elevated levels of plasma homocysteine and other aminothiols strongly correlate with manifestations of vascular dysfunction in atherosclerosis, coronary heart disease, myocardial infarction, stroke, and thrombosis, which makes it possible to isolate homocysteine as an independent risk factor for CSD progression.Our objective is to evaluate intestinal microbiome metabolism indicators and plasma aminothiols as early CVD risk markers in emergency response officers of the Ministry of Emergency Situations of Russia.Methodology. A comprehensive clinical and laboratory examination was performed in 96 emergency response male officers of the Russian Ministry of Emergency Situations at a regular medical check-up in the outpatient center of the Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg. The average age of response officers was (35.9 ± 0.8) years, with average work experience in the EMERCOM of Russia of (8.8 ± 0.5) years. All emergency response officers were split in 3 groups: group 1 included 56 practically healthy males, group 2 - 20 males with risk of CVD development, group 3 - 20 males with established CVD diagnosis. Chromatography with mass-spectrometric determination of short-chain fatty acids (SCFAs), trimethylamine N-oxide (TMAO) and aminothiols was performed in plasma samples from all examined patients.Results and analysis. TMAO level was elevated by 30 % in group 3 compared to group 1. 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引用次数: 0

摘要

的相关性。从事压力较大职业的个人,包括俄罗斯紧急情况部的应急官员(消防员和救援人员),容易早发循环系统疾病(CSD)。在深入调查中,紧急事故应急中心的人员对CSD的检出率超过10%。早期的研究报告称,CSD风险因素在俄罗斯应急军官中普遍存在。因此,有必要尽快查明易患慢性疾病的人,以便使俄罗斯紧急情况部的高素质专业人员保持健康和长寿。动脉粥样硬化的病理生理机制影响血管系统、免疫系统和脂质代谢之间复杂的相互作用。有证据表明,肠道微生物群直接或间接地加剧了动脉粥样硬化的所有复合危险因素,因此在CSD的发展中起着重要作用。大量研究表明,血浆同型半胱氨酸和其他氨基硫醇水平升高与动脉粥样硬化、冠心病、心肌梗死、卒中和血栓形成等血管功能障碍的表现密切相关,这使得同型半胱氨酸成为CSD进展的独立危险因素成为可能。我们的目的是评估肠道微生物代谢指标和血浆氨基硫醇作为俄罗斯紧急情况部应急反应官员的早期心血管疾病风险标志物。在圣彼得堡俄罗斯紧急情况部Nikiforov俄罗斯紧急和辐射医学中心门诊中心的定期体检中,对俄罗斯紧急情况部的96名男性应急官员进行了全面的临床和实验室检查。响应人员的平均年龄为(35.9±0.8)岁,在俄罗斯EMERCOM的平均工作经验为(8.8±0.5)年。所有应急响应人员被分为3组:1组包括56名实际健康的男性,2 - 20名有心血管疾病发展风险的男性,3 - 20名确诊为心血管疾病的男性。采用色谱-质谱法测定所有患者血浆样品中的短链脂肪酸(SCFAs)、三甲胺n -氧化物(TMAO)和氨基硫醇。结果和分析。与1组相比,3组TMAO水平升高30%。与1组相比,2组和3组的乙酸水平分别下降了32%和45%。3组血浆戊酸和丁酸分别比1组降低1.9倍和2.5倍,比2组降低2倍。结果发现,3组胱氨酸浓度比1组降低30%,还原性谷胱甘肽浓度比2组升高2倍。俄罗斯紧急情况部应急人员中SCFA、氨基硫醇和TMAO水平的变化表明代谢失衡,这扩大了我们对肠道微生物群与人体相互作用的认识。这对俄罗斯紧急情况部应急官员的CSD早期诊断、预防和纠正至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic significance of the level of short chain fatty acids and aminothiols in the EMERCOM of Russia response officers with risk factors for circulatory system diseases
Relevance. Individuals of stressful professions, including the emergency response officers (firefighters and rescuers) of the Ministry of Emergency Situations of Russia, are prone to the early onset of circulatory system diseases (CSD). At in-depth examinations the CSD detection rate in EMERCOM response officers is above 10%. Earlier studies report that CSD risk factors are widespread among EMERCOM of Russia response officers. Therefore, it is relevant to identify the predisposition to CSD as soon as possible in order to maintain good health and longevity among highly qualified professionals of the Ministry of Emergency Situations of Russia.The pathophysiological mechanism underlying progression of atherosclerosis affects complicated interactions between vasculature, immune system and lipid metabolism. Evidence shows that intestinal microbiome exacerbates all compound risk factors for atherosclerosis, both directly and indirectly, thus playing an important role in CSD development.Numerous studies revealed that elevated levels of plasma homocysteine and other aminothiols strongly correlate with manifestations of vascular dysfunction in atherosclerosis, coronary heart disease, myocardial infarction, stroke, and thrombosis, which makes it possible to isolate homocysteine as an independent risk factor for CSD progression.Our objective is to evaluate intestinal microbiome metabolism indicators and plasma aminothiols as early CVD risk markers in emergency response officers of the Ministry of Emergency Situations of Russia.Methodology. A comprehensive clinical and laboratory examination was performed in 96 emergency response male officers of the Russian Ministry of Emergency Situations at a regular medical check-up in the outpatient center of the Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg. The average age of response officers was (35.9 ± 0.8) years, with average work experience in the EMERCOM of Russia of (8.8 ± 0.5) years. All emergency response officers were split in 3 groups: group 1 included 56 practically healthy males, group 2 - 20 males with risk of CVD development, group 3 - 20 males with established CVD diagnosis. Chromatography with mass-spectrometric determination of short-chain fatty acids (SCFAs), trimethylamine N-oxide (TMAO) and aminothiols was performed in plasma samples from all examined patients.Results and analysis. TMAO level was elevated by 30 % in group 3 compared to group 1. Acetic acid level decrease by 32 % was found in group 2 and by 45 % in group 3 compared to group 1.Plasma valeric and butyric acids were decreased by 1.9 and 2.5 times respectively in group 3 compared to group 1, as well as by 2 times in group 3 compared to group 2. It was found that in group 3 cystine concentration was decreased by 30 % compared to group 1 and reduced glutathione was elevated by 2 times compared to group 2.Conclusion. The revealed changes in the level of SCFA, aminothiols and TMAO in emergency response officers of the Ministry of Emergency Situations of Russia indicate a metabolic imbalance, which expands our understanding of the interactions between the intestinal microbiome and human body. This is fundamentally important for CSD early diagnosis, prevention and correction in emergency response officers of the Russian Ministry of Emergency Situations.
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