O. Ayandipo, G. Ogun, O. Ajagbe, O. Adegoke, O. Adepoju, A. Rahman, Chioma Ajuyah, A. Orunmuyi, O. Shittu
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引用次数: 0
摘要
背景:胃肠道间质瘤(gist)具有特定的免疫组织化学和遗传特征。本研究调查了撒哈拉以南非洲一家主要转诊医院54例GIST患者的临床病理特征和手术结果。方法:这项回顾性横断面单中心研究描述了1999年至2019年在尼日利亚一家三级医院接受GIST手术的54例患者。所有病例均经免疫组织化学证实,并分析临床特征、临床处理和组织病理学资料。使用弗莱彻国立卫生研究院的标准确定复发风险。结果:患者平均年龄为57.6岁±15.3岁(11-81岁),多数患者(67%)术前行腹部ct扫描。最常见的表现是腹部肿块(48%)。胃是胃肠道间质瘤最常见的部位(37%)。肿瘤平均大小为8.9 cm (5 ~ 18 cm),肿瘤形态表现为梭形细胞型(75.9%)、梭形-上皮样混合细胞型(20.3%)和上皮样细胞型(3.7%)。总体而言,51%的患者有高复发风险。结论:本研究中GIST的临床病理特征与文献报道一致。在我们的设置中,风险概况的轻微变化可能是由于较晚的呈现。
Gastrointestinal stromal tumor experience in a surgical oncological unit in sub-Saharan Africa: A retrospective analysis
Background: Gastrointestinal stromal tumors (GISTs) are characterized by specific immunohistochemical and genetic features. This study investigated the clinicopathologic features and surgical outcomes of 54 patients with GIST in a major referral hospital in sub-Sahara Africa. Methods: This retrospective cross-sectional single-center study describes 54 patients who underwent surgery for GIST between 1999 and 2019 in a Nigerian Tertiary Hospital. All cases were confirmed by immunohistochemistry and were analyzed for clinical characteristics, clinical management, and histopathologic data. The risk of recurrence was determined using the Fletcher National Institutes of Health criteria. Results: The mean age of the patients was 57.6 years ± 15.3 (11–81 years), and most patients (67%) underwent abdominal computed tomography scans preoperatively. The most common presentation was an abdominal mass (48%). The stomach was the most common site of GIST (37%). The mean tumor size was 8.9 cm (5–18 cm), and tumor morphology showed spindle cell type (75.9%), mixed spindled-epithelioid (20.3%), and epithelioid (3.7%) cell types. Overall, 51% had a high risk for recurrence. Conclusion: The clinicopathologic features of GIST in this study are consistent with reports in the literature. Slight variations in risk profile may be due to late presentation in our settings.