苦楝减轻镉诱导的氧化应激和肾毒性

Johnson Olaleye Oladele, O. Oyewole, M. O. Oyeleke, O. Adewale, Oluwamuyiwa Emmanuel Adeloju
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引用次数: 4

摘要

镉是一种已知的工业毒物,会在肾脏中积聚并引起氧化损伤。本研究旨在探讨番荔枝籽提取物对镉介导的Wistar大鼠肾毒性的减弱作用。本研究选用Wistar白化大鼠28只,分为4组,每组7只。A组作为对照组,口服蒸馏水。B组、C组和D组分别给予5 mg/kg体重的氯化镉,C组和D组分别口服200和500 mg/kg体重的番荔枝乙醇籽提取物(ESEAM), B组不给药14 D。结果表明,镉显著(P<0.05)提高了血清尿素和肌酐水平。镉诱导大鼠肾脏氧化应激,MDA水平显著升高,抗坏血酸、GSH、GPx、SOD和CAT浓度显著降低。从酶促和非酶促抗氧化活性的生化评价、组织病理学变化和脂质过氧化率等方面评价了番荔枝籽提取物的抗肾毒性作用。ESEAM通过一种保护机制(包括减少增加的氧化应激)来预防镉诱导的恶化效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Annona muricata Attenuates Cadmium-Induced Oxidative Stress and Renal Toxicity in Wistar Rats
Cadmium is a known industrial toxicant that accumulates in the kidney and causes oxidative damage. The present study was carried out to evaluate the attenuating effects of Annona muricata seed extracts against cadmium mediated renal toxicity in Wistar rats. Twenty-eight (28) Wistar albino rats sorted into four groups of seven rats per group were used in this study. Group A serves as the control and received distilled water orally. Group B, C, and D were administered 5 mg/kg body weight cadmium chloride with Group C and D were treated daily with 200 and 500 mg/kg body weight of ethanolic seed extract of Annona muricata  (ESEAM)respectively by oral administration while group B was left untreated for 14 days. Results obtained showed that cadmium significantly (P<0.05) increased the serum level of urea and creatinine. Oxidative stress was induced by cadmium with a significant increase in MDA level and decrease concentration in ascorbic acid, GSH, GPx, SOD, and CAT in the kidney. Efficacy of Annona muricata seed extracts against renal toxicity was evaluated in terms of biochemical estimation of enzymatic and non-enzymatic antioxidant activities, histopathological changes, and rate of lipid peroxidation. Treatment with ESEAM prevented deteriorative effects induced by Cd through a protective mechanism that involved the reduction of increased oxidative stress.
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