COVID-19:免疫反应及其对疾病监测和治疗的影响

Q4 Health Professions

中华检验医学杂志 Pub Date : 2021-01-01 DOI:10.3760/cma.j.cn114452-20201120-00847

J. Hu, Yu Chen, Y. Zhou, Hang Yang

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引用次数: 0

摘要

目前，免疫功能紊乱被认为是导致2019冠状病毒病(COVID-19)患者临床症状加重的主要原因。本文从淋巴细胞亚群的异常动态，包括自然杀伤细胞和T细胞亚群计数的减少以及疾病进展过程中细胞因子的大量积累等方面，综述了COVID-19免疫反应的特点。本文还对关键淋巴细胞亚群变化的可能机制和细胞因子的动态进行了综述。因此，它为临床治疗提供了新的策略，并为药物发现提供了潜在的靶点。

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COVID-19: immune response and its implications for disease monitoring and therapy

Immune disorders are currently recognized as the major cause of aggravation of clinical symptoms in corona virus disease 2019 (COVID-19) patients. This review summarized the characteristics of the immune response to COVID-19 from the abnormal dynamics of lymphocyte subsets, including the decrease in the count of natural killer cell and T cell subsets and the large accumulation of cytokines during disease progression. This review also clarified the possible mechanisms of changes in key lymphocyte subsets and the dynamic of cytokines. Thus, it provided new strategies for clinical treatment and granted potential targets for drug discovery.

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来源期刊

中华检验医学杂志 Health Professions-Medical Laboratory Technology

CiteScore

0.40

自引率

0.00%

发文量

8037

期刊介绍：