耐药结核病:多重耐药和广泛耐药

Gudisa Bereda
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引用次数: 1

摘要

耐药结核病是一个相当大的全面公共卫生挑战,威胁着近几十年来在结核病预防和预防方面取得的重大进展。耐多药结核病是由对最有效的抗结核药物(异烟肼和利福平)具有耐药性的生物体引起的。结核菌对治疗中使用的抗生素具有耐药性的情况非常普遍,在所研究的所有国家都有发生。耐药性是由于治疗不足引起的,一旦结核菌产生耐药性,它们就会以与药物敏感型结核病类似的方式在人与人之间传播。多重耐药结核病序列来自先前耐药的生物体感染或可能在患者的治疗方案中取得进展。耐利福平结核是由对利福平不应答的细菌引起的,利福平是最具影响力的抗结核药物之一。这些患者需要耐多药结核病治疗。延伸耐药结核病是指由对异烟肼和利福平(即耐多药结核病)以及对所有氟喹诺酮类药物和任何二线抗结核注射药物(阿米卡星、卡那霉素或卷曲霉素)具有耐药性的生物体引起的结核病。当二线药物使用不当或管理不当并最终失效时,延展性耐药结核病就会进一步恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Medication resistant tuberculosis: multi drugresistant and extensively drug resistant
Medication-resistant tuberculosis is a considerable across-the-board public health challenge that menace’s the substantial advance made in tuberculosis heedfulness and precluding in current decades. Multidrug-resistant tuberculosis is caused by organisms that are resistant to the consummate effective anti-tuberculosis medications (isoniazid and rifampicin). Tuberculosis organisms resistant to the antibiotics used in its treatment are extendedly and happen in entire countries studied. Medication resistance noticed as a sequence of insufficient treatment and once tuberculosis organisms obtain resistance they can disseminate from person to person in the similar way as medication-sensitive tuberculosis. Multidrug-resistant tuberculosis sequences from either infection with organisms which are previously medication-resistant or perhaps advance in the program of a patient's treatment. Rifampicin-resistant tuberculosis is caused by bacteria that do not answered to rifampicin, one of the consummate influential anti- tuberculosis medications. These patients necessitated multidrug-resistant tuberculosis treatment. Extendedly medication-resistant tuberculosis is a figure of tuberculosis caused by organisms that are resistant to isoniazid and rifampicin (i.e. multidrug-resistant tuberculosis) as well as every fluoroquinolone and any of the second–line anti- tuberculosis injectable drugs (amikacin, kanamycin or capreomycin). Extendedly medication-resistant tuberculosis can elaborate when second-line medications are used incorrectly or wrongly managed and upon become ineffective.
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