伊朗人群非酒精性脂肪肝患者脂联素水平与生化变量和胰岛素抵抗的关系

مجتبی رحمانی, معصومه نژادعلی, جواد رستگارمقدم
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引用次数: 1

摘要

背景:非酒精性脂肪性肝病是世界范围内最重要的慢性肝病之一。脂肪因子是参与非酒精性脂肪肝发病机制的多肽激素。脂联素是一种脂肪因子,可以刺激肌肉中的脂肪酸氧化,并在胰岛素敏感性的发展中发挥作用。本研究旨在探讨血浆脂联素与非酒精性脂肪肝的关系。材料与方法:选取80例非酒精性脂肪肝患者和80例对照组进行病例与对照研究。血浆脂联素和胰岛素水平采用ELISA试剂盒(Mercodia公司,瑞典)测定,其他变量采用标准方法测定。采用SPSS 19版软件进行统计分析。结果:非酒精性脂肪肝患者血浆脂联素显著低于对照组(p值<0.001)。而非酒精性脂肪肝患者的体重指数、血清转氨酶、血清甘油三酯、收缩压、血清胰岛素和胰岛素抵抗水平均显著高于对照组(p<0.01)。脂联素与血清转氨酶、甘油三酯、胰岛素抵抗呈负相关(P<0.05),与脂蛋白不相关。结论:结果表明非酒精性脂肪肝患者脂联素水平降低。脂联素水平与肝转氨酶和胰岛素抵抗呈负相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of adiponectin level with biochemical variables and insulin resistance in patients with non-alcoholic fatty liver disease in an Iranian population
Background: Non-alcoholic fatty liver disease is one of the most important chronic liver disorders worldwide. Adipokines are polypeptide hormones that participate in the pathogenesis of non-alcoholic fatty liver disease. Adiponectin is an adipokine that stimulates fatty acid oxidation in muscle and plays a role in the development of insulin sensitivity. This study aimed to investigate the association between plasma adiponectin and nonalcoholic fatty liver disease. Materials and methods: This case and control study was conducted on 80 non-alcoholic fatty liver disease patients and 80 participants as control group. Plasma levels of adiponectin and insulin were measured by ELISA kit (Mercodia Company, Sweden) and other variables were determined by standard methods. Statistical analysis was performed using SPSS software, version 19. Results: Plasma adiponectin was significantly lower in non-alcoholic fatty liver disease patients than control (p-value<0.001). Whereas, subjects with non-alcoholic fatty liver disease had significantly higher levels of body mass index, serum transaminases, serum triglycerides, systolic blood pressure, serum insulin and insulin resistance compared to control group (p<0.01). An inverse correlation was observed between adiponectin with serum transaminases, triglycerides and insulin resistance (P<0.05), while it did not correlate with lipoproteins. Conclusion: The results indicate that adiponectin levels are reduced in individuals with non-alcoholic fatty liver disease. Adiponectin levels are inversely correlated with liver transaminases and insulin resistance.
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