查尔酮和吡唑啉的合成及其抗菌活性

R. Umadevi
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引用次数: 1

摘要

查尔酮是1,3-二苯基-2-丙烯-1- 1,其中两个芳香环由三个碳?,?-不饱和羰基体系。它们显示出广泛的生物活性。在此基础上,提出了以查尔酮为原料合成新型吡唑啉的方法。用不同的芳香族化合物对2-乙酰基-5-溴噻吩进行处理制备查尔酮。这些查尔酮与盐酸苯基肼缩合。吡啶为催化剂得到3-(5-溴噻吩-2基)-1-苯基- 1h -吡唑衍生物。对合成的化合物进行了熔点、薄层色谱、红外光谱和核磁共振氢谱的表征。对革兰氏阳性菌枯草芽孢杆菌和矮芽孢杆菌、革兰氏阴性菌大肠杆菌和普通芽孢杆菌具有抑菌活性,对黑霉杆菌和低温芽孢杆菌具有抑菌活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and antimicrobial activity of chalcones and pyrazolines
Chalcones are 1,3-diphenyl-2-propene-1-one, in which two aromatic rings are linked by a three carbon ?,?-unsaturated carbonyl system. They have displayed a broad spectrum of biological activities. In this view it was proposed to synthesize some novel pyrazolines from chalcones. Chalcones are prepared by treating 2-acetyl-5-bromothiophene with different aromatic compounds. These chalcones on condensation with phenyl hydrazine HCl. pyridine as a catalyst gave 3-(5-bromothiphene-2yl)-1-phenyl-1H-pyrazole derivatives. The synthesized compounds have been characterized by their melting point, TLC, IR and 1H NMR spectral data. They have been screened for their antibacterial activity against Gram positive bacteria B.subtillis & B.pumilus and Gram negative bacteria E. coli & P.vulgaris and antifungal against A.niger & p.crysogenium .
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