食管鳞状细胞癌癌前病变的分子改变

国际肿瘤学杂志 Pub Date : 2019-07-08 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.07.009

Chen Chang

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引用次数: 0

摘要

食管鳞状细胞癌(ESCC)是世界上最主要的恶性肿瘤之一。ESCC由癌前病变逐渐发展而来。生物标志物的研究主要集中在核酸和蛋白质方面，包括基因组DNA的细胞遗传学异常、扩增、缺失、突变、断裂和融合，mRNA、microRNA (miRNA)和长链非编码RNA (lncRNA)在RNA水平上的表达变化，蛋白质的表达水平、亚细胞定位和翻译后修饰。研究食管癌前病变和早期食管癌的分子变化将有助于探索食管癌早期诊断的生物标志物和干预靶点。关键词:食管肿瘤;肿瘤，鳞状细胞;DNA;RNA;蛋白质;癌前病变

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Molecular alterations in precancerous lesions of esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most predominant malignancies worldwide. ESCC develops gradually from the precancerous lesions. The researches about biomarkers mainly concentrate in the nucleic acid and protein, including cytogenetic abnormalities, amplifications, deletions, mutations, breakage and fusions of genomic DNA, expression changes of mRNA, microRNA (miRNA) and long non-coding RNA (lncRNA) in RNA level, and expression level, subcellular localization, and post-translational modifications of proteins. Studies on the molecular alterations in precancerous lesions and early cancer of the esophagus will contribute to the exploration of biomarkers for early diagnosis and intervention targets for this disease. Key words: Esophageal neoplasms; Neoplasms, squamous cell; DNA; RNA; Proteins; Precancerous lesions

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国际肿瘤学杂志

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12123

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