TGF-β信号通过调节Uhrf1活性控制Foxp3甲基化和T细胞分化

The Tokushima journal of experimental medicine Pub Date : 2019-09-12 DOI:10.1084/jem.20190550

Xiang Sun, Yu Cui, Haiyun Feng, Haifeng Liu, Xiaolong Liu

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引用次数: 42

摘要

在Foxp3转录之前，DNA甲基化介导的抑制是如何被逆转的尚不清楚。在这里，Sun等人发现维持Foxp3甲基化的表观遗传调控因子Uhrf1被TGF-β信号下调，并为iT regg细胞分化过程中Foxp3的表观遗传调控提供了新的见解。

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TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity

How DNA methylation–mediated repression is reversed before Foxp3 transcription is unclear. Here, Sun et al. show that the epigenetic regulator Uhrf1, which maintained Foxp3 methylation, is down-regulated by TGF-β signaling and provide novel insight into the epigenetic regulation of Foxp3 during iT reg cell differentiation.

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The Tokushima journal of experimental medicine

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