阿戈美拉汀对大鼠创伤性脑损伤所致认知缺陷的保护作用:神经递质的可能作用

Current Psychopharmacology Pub Date : 2019-01-23 DOI:10.2174/2211556007666180601100641

T. Kaur, Puneet Kumar, Sumit Jamwal

{"title":"阿戈美拉汀对大鼠创伤性脑损伤所致认知缺陷的保护作用:神经递质的可能作用","authors":"T. Kaur, Puneet Kumar, Sumit Jamwal","doi":"10.2174/2211556007666180601100641","DOIUrl":null,"url":null,"abstract":"Traumatic brain injury (TBI) is the leading cause of death and disability among children and young adults worldwide. These patients often have short and long term cognitive, behavioral and emotional impairments. The 5-HT2C and melatonin receptors are known to have involvement in memory functions. The aim of the present study is to find the beneficial effect of agomelatine (selective 5HT2C antagonist and melatonin receptor agonist) against weight drop induced traumatic brain injury in rats. The weight-drop model closely mimics the real life TBI. Injury was induced by dropping a weight of 450 gm from a height of 1 meter through a hollow metallic tube onto the exposed skull of rats under anesthesia. After 14 days of TBI the agomelatine (10, 20, and 40 mg/kg p.o. daily) treatment was given for next 14 days (i.e. till 28 th","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"290 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Protective Effect of Agomelatine on Traumatic Brain Injury Induced Cognitive Deficit in Rats: Possible Role of Neurotransmitters\",\"authors\":\"T. Kaur, Puneet Kumar, Sumit Jamwal\",\"doi\":\"10.2174/2211556007666180601100641\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Traumatic brain injury (TBI) is the leading cause of death and disability among children and young adults worldwide. These patients often have short and long term cognitive, behavioral and emotional impairments. The 5-HT2C and melatonin receptors are known to have involvement in memory functions. The aim of the present study is to find the beneficial effect of agomelatine (selective 5HT2C antagonist and melatonin receptor agonist) against weight drop induced traumatic brain injury in rats. The weight-drop model closely mimics the real life TBI. Injury was induced by dropping a weight of 450 gm from a height of 1 meter through a hollow metallic tube onto the exposed skull of rats under anesthesia. After 14 days of TBI the agomelatine (10, 20, and 40 mg/kg p.o. daily) treatment was given for next 14 days (i.e. till 28 th\",\"PeriodicalId\":10751,\"journal\":{\"name\":\"Current Psychopharmacology\",\"volume\":\"290 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/2211556007666180601100641\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2211556007666180601100641","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 3

摘要

创伤性脑损伤(TBI)是全世界儿童和年轻人死亡和残疾的主要原因。这些患者通常有短期和长期的认知、行为和情感障碍。已知5-HT2C和褪黑激素受体与记忆功能有关。本研究旨在探讨阿戈美拉汀(选择性5HT2C拮抗剂和褪黑激素受体激动剂)对大鼠减重所致外伤性脑损伤的有益作用。减肥模型与现实生活中的创伤性脑损伤非常相似。在麻醉状态下，将450gm的重量从1米高度通过空心金属管落在暴露在外的大鼠颅骨上造成损伤。创伤性脑损伤14天后给予阿戈美拉汀(每日10、20和40 mg/kg)治疗，持续14天(即至28天)

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Protective Effect of Agomelatine on Traumatic Brain Injury Induced Cognitive Deficit in Rats: Possible Role of Neurotransmitters

Traumatic brain injury (TBI) is the leading cause of death and disability among children and young adults worldwide. These patients often have short and long term cognitive, behavioral and emotional impairments. The 5-HT2C and melatonin receptors are known to have involvement in memory functions. The aim of the present study is to find the beneficial effect of agomelatine (selective 5HT2C antagonist and melatonin receptor agonist) against weight drop induced traumatic brain injury in rats. The weight-drop model closely mimics the real life TBI. Injury was induced by dropping a weight of 450 gm from a height of 1 meter through a hollow metallic tube onto the exposed skull of rats under anesthesia. After 14 days of TBI the agomelatine (10, 20, and 40 mg/kg p.o. daily) treatment was given for next 14 days (i.e. till 28 th

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Psychopharmacology

自引率

0.00%

发文量