贝伐单抗生物仿制药在印度转移性结直肠癌中的实际应用和接受度

L. Patel, Shreekant Sharma, D. Bunger
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引用次数: 0

摘要

背景:描述印度生物仿制药贝伐单抗治疗转移性结直肠癌(mCRC)的患者特征和使用模式。方法:这项现实世界的回顾性分析包括2021年4月至2022年3月期间接受贝伐单抗生物仿制药治疗的成年患者。结果:共纳入1125例接受贝伐单抗生物仿制药化疗的mCRC患者。平均诊断年龄为57.8岁。患者以男性为主(71%),年龄在41 ~ 76岁之间。原发部位为右结肠(52.6%),其次为左结肠(29.2%)和直肠(17.3%),多数患者肿瘤分级高(88.7%)。大多数患者接受以贝伐单抗为基础的生物类似药化疗作为一线治疗(61.3%),其次是二线(31.9%)和三线治疗(6.8%)。与生物类似药贝伐单抗联合使用时,FOLFOX(叶酸、5-氟尿嘧啶和奥沙利铂)是最常用的方案(42.9%),其次是CAPOX(卡培他滨和奥沙利铂,26.5%)和FOLFIRI(叶酸、5-氟尿嘧啶和伊立替康,22.8%)。结论:基于贝伐单抗的生物类似药化疗在印度的临床环境中被广泛应用于mCRC患者的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Real-world utilization and acceptance of biosimilar bevacizumab in metastatic colorectal cancer in India
Background: To describe the patient characteristics and usage pattern of biosimilar bevacizumab for the treatment of metastatic colorectal cancer (mCRC) in India.Methods: This real-world, retrospective analysis included adult patients receiving biosimilar bevacizumab between April 2021 and March 2022.Results: A total of 1125 patients with mCRC who received biosimilar bevacizumab-based chemotherapy were included. The mean age at diagnosis was 57.8 years. Majority of the patients were males (71%) and belonged to the age groups of 41-76 years. The primary tumor site was right colon (52.6%) followed by left colon (29.2%) and rectum (17.3%), and the tumor grade was reported as high in most (88.7%) of the patients. Majority of patients received biosimilar bevacizumab-based chemotherapy as first-line therapy (61.3%), followed by second-line (31.9%) and third-line therapy (6.8%). In combination with biosimilar bevacizumab, FOLFOX (folinic acid, 5-fluorouracil, and oxaliplatin) was the most commonly administered regimen (42.9%), followed by CAPOX (capecitabine and oxaliplatin, 26.5%) and FOLFIRI (folinic acid, 5-fluorouracil, and irinotecan, 22.8%).Conclusions: Biosimilar bevacizumab-based chemotherapy is being widely used in real‑world clinical setting in India for the management of patients with mCRC.
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