胫骨后神经电刺激治疗难治性膀胱过度活跃妇女的生活质量

Francine O. Fischer-Sgrott, E. F. Manffra, W. F. S. B. Junior
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引用次数: 18

摘要

目的:探讨经皮胫神经刺激(PTNS)对女性膀胱过动症(OAB)患者生活质量(QoL)的影响。方法:对11名在尿动力学检查中出现逼尿肌过度活动的妇女进行非对照临床试验。所有受试者之前都接受过抗胆碱能药物治疗,没有反应。治疗包括12次PTNS疗程,每次30分钟,每周两次。使用电刺激器Dualpex 961®(Quark medical)。所选择的评估生活质量的工具是国王健康问卷(KHQ)和“失禁国际咨询问卷-短格式”(ICIQ-SF)。在治疗前后分别进行问卷调查。结果:KHQ的以下领域评分有显著改善:尿失禁影响(74.55±27.75 vs 38.18±13.82);P =0.008),角色限制(66.45±25.89∶26.91±11.22;P =0.008),生理限制(73.91±29.46 vs 30.91±12.79;P =0.008),社会限制(39.18±35.60 vs 17.45±12.26;P =0.028),个人关系(25.64±29.16 vs 10.45±15.23;P =0.043),情绪(65.82±38.56∶26.00±20.45;P =0.005),睡眠/能量(39.18±37.51∶16.45±18.17;P =0.012)和严重程度测量(62.00±17.70 vs 33.00±16.59;P = 0.003),但一般健康知觉(51.36±30.75∶37.73±25.63;p = 0.068)。在ICIQ-SF评分中,也有可能观察到显著的改善(10.09±6.50 vs 3.73±3.00;p = 0.008)。结论:PTNS治疗可改善膀胱过度活动且抗胆碱能药物治疗无效的女性患者的生活质量。因此,PTNS可以被认为是OAB治疗的一个很好的选择,因为与其他治疗方法相比,PTNS安全且便宜。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Qualidade de vida de mulheres com bexiga hiperativa refratária tratadas com estimulação elétrica do nervo tibial posterior
OBJECTIVE: To investigate the effect of percutaneous tibial nerve stimulation (PTNS) in the quality of life (QoL) of women with overactive bladder (OAB). METHODS: uncontrolled clinical trial with 11 women that presented overactivity of the detrusor muscle in urodynamic tests. All of the subjects were previously treated with anticholinergic medication, without response. The treatment consisted of 12 PTNS sessions of 30 minutes each, two times a week. The electrical stimulator Dualpex 961® (Quark medical) was used. The instruments chosen to evaluate QoL were the King's Health Questionnaire (KHQ) and the "International Consultation on Incontinence Questionnaire - Short-Form" (ICIQ-SF). The questionnaires were applied before and after the treatment. RESULTS: There was a significant improvement in the following domain scores of the KHQ: incontinence impact (74.55±27.75 versus 38.18±13.82; p=0.008), role limitations (66.45±25.89 versus 26.91±11.22; p=0.008), physical limitations (73.91±29.46 versus 30.91±12.79; p=0.008), social limitations (39.18±35.60 versus 17.45±12.26; p=0.028), personal relationships (25.64±29.16 versus 10.45±15.23; p=0.043), emotions (65.82±38.56 versus 26.00±20.45; p=0.005), sleep/energy (39.18±37.51 versus 16.45±18.17; p=0.012) and severity measures (62.00±17.70 versus 33.00±16.59; p= 0.003), except for general health perception (51.36±30.75 versus 37.73±25.63; p=0.068). In the ICIQ-SF scores it was also possible to observe a significant improvement (10.09±6.50 versus 3.73±3.00; p=0.008). CONCLUSIONS: The PTNS treatment improved the QoL of women with overactive bladder and refractory to anticholinergic medication. Therefore, PTNS can be considered a good alternative for OAB treatment as it is safe and inexpensive compared to other therapeutic approaches.
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