帕米膦酸钠与唑来膦酸治疗骨佩吉特病

M. Colina, G. Ciancìo, F. Trotta
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引用次数: 0

摘要

骨佩吉特病(PDB)是一种以过度和异常的骨重塑为特征的疾病。由于骨重塑率高,双磷酸盐,特别是帕米膦酸盐和较新的唑仑膦酸盐,被用于治疗PDB。无症状但活性PDB的存在代表了一种针对预防后期并发症的治疗指征。治疗的另一个适应症是累及可能引起严重并发症的骨节。帕米膦酸钠治疗PDB已有悠久的历史。更常用的方案是在3 - 21天内以1mg /min的输注速度静脉滴注60mg帕米膦酸盐3 - 6次。唑仑膦酸盐(每年5毫克)是目前使用的最有效的氨基双膦酸盐。这种首要地位承认抑制法尼基焦磷酸盐合成酶的能力和对羟基磷灰石晶体的高亲和力是原因之一。帕米膦酸盐和唑仑膦酸盐对PDB均有效,且后者具有循证优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pamidronate and Zoledronic Acid in the Treatment of Paget’s Disease of Bone
Paget’s disease of bone (PDB) is a condition characterized by excessive and abnormal bone remodelling. Due to a high rate of bone remodelling, bisphosphonates, and especially pamidronate and the newer zolendronate, are indicated in the treatment of PDB. The presence of asymptomatic, but active PDB represents an indication for treatment aimed at preventing later complications. An additional indication for treatment is the involvement of skeletal segments that may give rise to severe complications. Pamidronate has a long history in the treatment of PDB. The more utilised regimen is 3 to 6 i.v. infusion of 60 mg of pamidronate at an infusion rate of 1 mg/min within 3–21 days. Zolendronate (5 mg once yearly) is the most powerful amino-bisphosphonate currently used. This primacy recognizes both the ability to inhibit the farnesyl-pyrophosphate synthetase and the higher affinity to hydroxyapatite crystals as a cause. Both pamidronate and zolendronate are effective in PDB, with an evidence-based superiority of the latter.
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