老年2型糖尿病患者肌肉质量的床边试验

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
K. Madden, B. Feldman, Shane Arishenkoff, G. Meneilly
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引用次数: 0

摘要

目的糖尿病和肌肉减少症在老年人中经常共存,提示两者可能存在双向关联。可用的床边测量肌肉质量包括床边超声(MT,股四头肌厚度)和生物电阻抗分析(BIA)。我们研究了超声测量和BIA测量老年人肌肉与老年糖尿病患者的力量、表现和虚弱之间的关系。DesignCross-sectional研究。方法81例(年龄≥65岁;平均年龄80.8±0.6岁,女性27人,男性53人)依次从老年医学诊所招募。测量每位受试者的瘦体质量(LBM,通过BIA,单位为kg)、握力、步态速度、心血管健康研究指数(脆弱)和MT(单位为cm)。所有初始模型都根据生理性别进行了调整。结果在我们的最终简约模型中,只有MT(相对于LBM)与握力呈显著相关(标准化β = 0.217±0.078;p = 0.007)和虚弱(标准化β = 0.276±0.109;P = 0.013)。MT和LBM均未显示出受试者表现(步态速度)的显著相关性。结论与BIA类似,床旁超声测量的肌肉厚度与老年糖尿病患者的握力和虚弱都有很强的相关性,这表明床旁超声测量的肌肉厚度可能是评估老年糖尿病患者肌肉强度的一种更有用的临床方法。无论是BIA还是MT测量的受试者肌肉量都没有显示出与我们的表现指标(步态速度)有任何关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bedside tests of muscle mass in older adults with Type 2 diabetes
Objective

Diabetes and sarcopenia often coexist in older adults, suggesting a possible bidirectional association. Available bedside measures of muscle mass consist of bedside ultrasound (MT, quadriceps muscle thickness) and Bioelectrical Impedance Analysis (BIA). We examined the association between ultrasound measures and BIA measures of muscle in older adults with measures of strength, performance and frailty in older adults with diabetes.

Design

Cross-sectional study.

Methods

81 subjects (age ≥ 65; mean age 80.8 ± 0.6 years, 27 women, 53 men) were recruited sequentially from geriatric medicine clinics. Each subject had Lean Body Mass (LBM, by BIA, in kg), grip strength, gait speed, Cardiovascular Health Study index (frailty) and MT (in cm) measured. All initial models were adjusted for biological sex.

Results

In our final parsimonious models, only MT (as opposed to LBM) showed a significant correlation with grip strength (Standardized β = 0.217 ± 0.078; p = 0.007) and frailty (Standardized β = 0.276 ± 0.109; p = 0.013). Neither MT or LBM showed a significant association with subject performance (gait speed).

Conclusions

Unlike BIA, bedside ultrasound measures of muscle thickness showed strong associations with both grip strength and frailty in the older adult population with diabetes, suggesting that bedside measures of MT might be a more clinically useful modality to assess muscularity in this patient population. Neither BIA or MT measures of subject muscularity showed any association with our performance indicator (gait speed).

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来源期刊
AIMS Medical Science
AIMS Medical Science MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
14.30%
发文量
20
审稿时长
12 weeks
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