非洲绿松石鳉Nothobranchius furzeri作为衰老研究的模型

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2018-03-01 DOI:10.1016/j.ddmod.2018.12.001

Hanna Reuter , Johannes Krug , Peter Singer , Christoph Englert

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引用次数: 9

摘要

furzeri Nothobranchius是一种非洲鳉鱼，平均寿命非常短，只有3到7个月。尽管N. furzeri的寿命很短，但它的衰老迹象与哺乳动物的衰老非常相似。2015年，furzeri N. furzeri基因组的参考序列已经发表。此外，利用CRISPR/Cas9对鳉鱼进行转基因和基因组工程的研究也已在近期建立。也有研究表明furzeri可接受药物干预。在这篇综述中，我们将讨论是什么使N. furzeri成为研究衰老的有价值的模型，以及它是否也可以用于药物发现。

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The African turquoise killifish Nothobranchius furzeri as a model for aging research

Nothobranchius furzeri is an African killifish with an exceptionally short median life span of 3 to 7 months. Despite its short life span N. furzeri displays signs of aging that are highly reminiscent of mammalian aging. In 2015, reference sequences for the N. furzeri genome have been published. In addition, transgenesis and genomic engineering of killifish using CRISPR/Cas9 have been recently established. It has also been shown that N. furzeri is amenable to pharmacologic intervention. In this review we will discuss what makes N. furzeri a valuable model for research on aging and whether it could also be used for drug discovery.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.