运动改变血清肺蛋白浓度

Christopher J Nanson , Jefferey L Burgess , Marjorie Robin , Alfred M Bernard
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引用次数: 32

摘要

为了确定运动对血清Clara细胞蛋白(CC16)和表面活性剂相关蛋白A (SP-A)水平的影响,我们采集了14名健康受试者在最大运动和次最大运动后1小时的血清。健康志愿者在不同的场合参加了对照(无运动)会议,模拟消防任务30分钟(n=14),以及接近最大心率的间歇跑步机运动60分钟(n=10)。运动后1 h采集血清和诱导痰。分析诱导痰液中肿瘤坏死因子α (TNF-α),一种由肺巨噬细胞产生的炎症介质。血清CC16水平在消防任务组(15±13 μg/L vs. 9±4 μg/L, P=0.047)和跑步机运动组(15±8 μg/L vs. 9±4 μg/L, P= 0.01)均显著升高。与对照组相比,血清SP-A浓度在消防任务(247±106 μg/L vs 247±96 μg/L, P=0.84)或跑步机运动(251±89 μg/L vs 285±87 μg/L, P=0.44)下均无变化。痰上清中TNF-α浓度与对照组无显著差异。这些结果表明运动后血清CC16升高。当使用血清CC16来确定在运动和有毒暴露相结合的环境中是否存在肺损伤时,必须考虑到这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exercise alters serum pneumoprotein concentrations

To determine the effect of exercise on serum levels of Clara cell protein (CC16) and surfactant-associated protein A (SP-A), serum was collected from 14 healthy subjects 1 h after maximal and sub-maximal exercise. Healthy volunteers participated on separate occasions in a control (no exercise) session, simulated firefighting tasks for 30 min (n=14), and intermittent treadmill exercise at near maximal heart rates for 60 min (n=10). Serum samples and induced sputum samples were collected 1 h post exercise. Induced sputum fluid was analyzed for tumor necrosis factor alpha (TNF-α), an inflammatory mediator produced by pulmonary macrophages. Serum CC16 levels increased significantly with both firefighting tasks (15±13 μg/L vs. 9±4 μg/L, P=0.047) and treadmill exercise (15±8 μg/L vs. 9±4 μg/L, P<0.01). Serum SP-A concentrations did not change compared to control with either firefighting tasks (247±106 μg/L vs. 247±96 μg/L, P=0.84) or treadmill exercise (251±89 μg/L vs. 285±87 μg/L, P=0.44). TNF-α concentrations in sputum supernatant showed no significant difference from controls. These results show an increase in serum CC16 after exercise. This must be considered when utilizing serum CC16 to determine the presence of lung injury in settings that combine exercise and toxic exposures.

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