螺旋微通道耦合收缩-膨胀阵列以增强基于微流体的颗粒/细胞分离

IF 1.1 4区工程技术 Q4 MECHANICS

International Journal of Computational Fluid Dynamics Pub Date : 2022-01-02 DOI:10.1080/10618562.2022.2053114

Z. Shahraki, M. Navidbakhsh, Robert A. Taylor

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引用次数: 2

摘要

在基于微流控惯性的悬浮粒子聚焦领域，目前还没有将梯形螺旋微通道和收缩膨胀阵列(CEA)这两个主要研究方向结合起来的研究。本文通过研究在三种不同流速(即3,6和6)下的均匀横截面设计下螺旋通道内的两种提议的cea(平滑和突然)来解决这一差距。在OpenFOAM中采用拉格朗日-欧拉(LE)方法求解了质量和动量守恒方程，并采用相位之间的四向耦合。结果表明，在一定流速下，在螺旋微通道中加入平滑过渡cea，在保持高分离效率(接近100%)的同时，降低了聚焦时间(约29%)和细胞裂解概率(约52%)。总的来说，本研究为颗粒的被动微流控聚焦开辟了一个有希望的新方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Coupling Contraction-expansion Arrays with Spiral Microchannels to Enhance Microfluidic-Based Particle/Cell Separation

In the field of microfluidic inertial-based focusing of suspended particles, no research has been conducted to bring together two of the main directions of research, trapezoid spiral microchannels and contraction-expansion array (CEA)s. This paper addresses that gap by investigating two proposed CEAs (smooth and abrupt) inside a spiral channel compared to a uniform cross-section design at three different flow rates (i.e. 3, 6, and . The conservation equations of mass and momentum with a Lagrangian’-Eulerian (LE) approach are solved in OpenFOAM, using a four-way coupling between the phases. The results indicate that adding smooth transition CEAs to spiral microchannels, at a nominal flow rate , decreases the focusing duration (by about 29%) and the cell lysis probability (by about 52%) while keeping the separation efficiency high (nearly 100%). Overall, this study opens a promising new, integrated direction for passive microfluidic focusing of particles.

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来源期刊

International Journal of Computational Fluid Dynamics 物理-力学

CiteScore

2.70

自引率

7.70%

发文量

审稿时长

3 months

期刊介绍： The International Journal of Computational Fluid Dynamics publishes innovative CFD research, both fundamental and applied, with applications in a wide variety of fields. The Journal emphasizes accurate predictive tools for 3D flow analysis and design, and those promoting a deeper understanding of the physics of 3D fluid motion. Relevant and innovative practical and industrial 3D applications, as well as those of an interdisciplinary nature, are encouraged.