妊娠外阴阴道念珠菌病患者念珠菌种类分布

I. Purnamasari, Evy Ervianti, D. Damayanti, Budi Prasetyo, L. Astari, Pepy D. Endraswari, M. Listiawan, C. Prakoeswa
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摘要

背景:外阴阴道念珠菌病(VVC)是女性最常见的生殖道疾病之一。分离的念珠菌种类的鉴定对指导经验性抗真菌治疗至关重要。目的:了解Soetomo博士综合学术医院妇产科门诊妊娠期引起外阴阴道念珠菌病的念珠菌种类,为临床提供科学依据。方法:在Dr. Soetomo综合学术医院妇产科门诊接受产前护理(ANC)的孕妇。研究对象在2021年3月至5月间的3个月内参加了一项横断面研究。经受试者知情同意后采集阴道拭子样本。使用CHROMagar培养物和VITEK 2紧凑物的特定颜色变化来鉴定念珠菌种类。结果:在研究期间,15例妊娠患者被诊断为VVC。研究中的大多数女性是性活跃年龄的孕妇,她们抱怨身体发白,生殖器发炎。从CHROMagar培养中分离出18株念珠菌,其中非白色念珠菌(61.1%)多于白色念珠菌(38.3%)。其中,非白色念珠菌分别为光秃念珠菌(54.4%)、都柏林念珠菌(36.3%)和副枯枝念珠菌(18.1%)。结论:本研究揭示了非白色念珠菌引起VVC的高发性。培养调查和鉴定念珠菌是避免抗真菌治疗敏感性降低和复发的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pattern of Candida Species Isolated from Patient with Vulvovaginal Candidiasis in Pregnancy
Background: Vulvovaginal candidiasis (VVC) is one of the most prevalent genital tract diseases in women. The identification of the isolated Candida species is critical for guiding empirical antifungal therapy. Purpose: To determine the Candida species that cause vulvovaginal candidiasis in pregnancy at the Obstetrics and Gynecology Outpatient Clinic, Dr. Soetomo General Academic Hospital, thus providing scientific and therapeutic benefits. Methods:  Pregnant woman receiving antenatal care (ANC) at Dr. Soetomo General Academic Hospital Obstetric and Gynecology Outpatient Clinic. Subjects were enrolled in a cross-sectional study during 3 months between March and May 2021. Vaginal swab samples were taken from subjects after informed consent. A specific color change in CHROMagar cultures and VITEK 2 compact were used to identify Candida species. Result: During the study period, 15 pregnant patients were diagnosed with VVC. The majority of the women in the study were pregnant women of sexually active age who complained of a whitish body and genital irritation. There were 18 candida isolates from CHROMagar cultures, with C. non albicans (61.1%) predominating over C. albicans (38.3%). With details, non albicans were C. glabrata (54.4%), C. dubliniensis (36.3%), and C. parapsilosis (18.1%). Conclusion: This study revealed a high prevalence of Candida non-albicans species causing VVC. Culture investigation and identification of Candida are critical to avoid diminished susceptibility to antifungal treatments and recurrence.
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