{"title":"以草酸为赋形剂的无环鸟苷共非晶化","authors":"S. Rohani, A. Sarkar","doi":"10.21065/1920-4159.1000251","DOIUrl":null,"url":null,"abstract":"The present article provides a novel technique for the co-amorphous formation of acyclovir and oxalic acid as an excipient. Designated as ACV-oxalic acid, methods for the preparation thereof and its use in pharmaceutical applications are described. The co-amorphous ACV-oxalic acid was characterized by powder X-ray diffraction, differential scanning calorimetry and thermogravimetric analysis. Stability with respect to relative humidity (RH) for the co-amorphous ACV-oxalic acid was evaluated and compared with the parent ACV. The aqueous solubility of the co-amorphous ACV-oxalic acid was significantly improved (about 8 times more soluble) at 35°C compared to that of the parent Acyclovir base.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"653 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2017-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Co-Amorphization of Acyclovir with Oxalic Acid as an Excipient\",\"authors\":\"S. Rohani, A. Sarkar\",\"doi\":\"10.21065/1920-4159.1000251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present article provides a novel technique for the co-amorphous formation of acyclovir and oxalic acid as an excipient. Designated as ACV-oxalic acid, methods for the preparation thereof and its use in pharmaceutical applications are described. The co-amorphous ACV-oxalic acid was characterized by powder X-ray diffraction, differential scanning calorimetry and thermogravimetric analysis. Stability with respect to relative humidity (RH) for the co-amorphous ACV-oxalic acid was evaluated and compared with the parent ACV. The aqueous solubility of the co-amorphous ACV-oxalic acid was significantly improved (about 8 times more soluble) at 35°C compared to that of the parent Acyclovir base.\",\"PeriodicalId\":15238,\"journal\":{\"name\":\"Journal of Applied Pharmacy\",\"volume\":\"653 1\",\"pages\":\"1-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21065/1920-4159.1000251\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21065/1920-4159.1000251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Co-Amorphization of Acyclovir with Oxalic Acid as an Excipient
The present article provides a novel technique for the co-amorphous formation of acyclovir and oxalic acid as an excipient. Designated as ACV-oxalic acid, methods for the preparation thereof and its use in pharmaceutical applications are described. The co-amorphous ACV-oxalic acid was characterized by powder X-ray diffraction, differential scanning calorimetry and thermogravimetric analysis. Stability with respect to relative humidity (RH) for the co-amorphous ACV-oxalic acid was evaluated and compared with the parent ACV. The aqueous solubility of the co-amorphous ACV-oxalic acid was significantly improved (about 8 times more soluble) at 35°C compared to that of the parent Acyclovir base.
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