男性慢性肾病患者血清催乳素水平的研究

Sahar Gamman, Fatma Hammad, Waleed A. Taha, Osama Bakheet, I. Ahmad
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摘要

背景:慢性肾脏疾病(CKD)起源于多种异质性疾病途径,在数月或数年内不可逆地改变肾脏的功能和结构。CKD的诊断建立在肾脏功能的慢性下降和肾脏结构性损害的基础上,其临床表现多种多样。CKD可能与血清催乳素(PRL)水平升高有关。除了性功能障碍外,PRL可能有一些参与动脉粥样硬化过程并导致胰岛素抵抗的生物学作用。它也可能与内皮功能障碍和脂质异常有关。目的评价男性慢性肾病患者血清PRL水平。研究对象为90名男性,年龄30 ~ 60岁。他们被分为两组:第一组包括60名诊断为慢性肾病的男性参与者,第二组包括30名年龄匹配的健康个体作为对照组。CKD组又分为代偿性CKD组和血透性CKD组。结果60例CKD患者中,2组48例(80%)患者血清PRL高于正常血清PRL。PRL与血清肌酐呈显著正相关(r=0.259, P0.05)。血液透析的CKD患者PRL水平高于代偿性CKD患者(P<0.05)。结论CKD与高泌乳素血症相关,多数患者存在高泌乳素血症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum prolactin level in male patients with chronic kidney diseases
Background Chronic kidney disease (CKD) arises from many heterogeneous disease pathways that alter the function and structure of the kidney irreversibly, over months or years. The diagnosis of CKD rests on establishing a chronic reduction in kidney function and structural kidney damage, which presents with varied clinical manifestations. CKD may be associated with elevation of serum prolactin (PRL) levels. In addition to sexual dysfunction, PRL may have several biologic actions that participate in the atherosclerotic process and lead to insulin resistance. It may also be associated with endothelial dysfunction and lipid profile abnormalities. Objective The objective of this work was to evaluate serum PRL level in male patients with CKD. Patients and methods This study was conducted on 90 male participants, aged 30–60 years old. They were divided into two groups: group 1 comprised 60 male participants diagnosed with CKD, and group 2 included 30 age-matched healthy individuals as a control group. CKD group was subdivided into compensated CKD and CKD on hemodialysis. Results Among 60 patients with CKD, 48 (80%) patients had elevated serum PRL compared with normal serum PRL in group 2. A significant positive correlation was found between PRL and serum creatinine (r=0.259, P<0.05) and a negative correlation was observed between PRL and estimated glomerular filtration rate (r=−0.259, P>0.05). Patients with CKD on hemodialysis had higher PRL level compared with patients with compensated CKD (P<0.05). Conclusion CKD is associated with hyperprolactinemia which was found in most patients.
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