{"title":"复合抑癌素脲衍生物的合成及生物学评价","authors":"V. Ramesh, G. Rao, B. Chakrapani, A. Chakravarthy","doi":"10.7598/cst2018.1525","DOIUrl":null,"url":null,"abstract":"A series of new combretastatin urea derivatives (12a-j) were synthesized by reacting of substituted aromatic isocyanates (11a-j) to the combretastatin pyrazole-amine. The synthesized derivatives 11a-j were evaluated for their cytotoxicity against four human cancer cell lines (breast, lung and ovarian). Among them, compounds 12a, 12c, 12d, 12f, 12g and 12i were showed potent anticancer activity.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":"61 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Synthesis and Biological Evaluation of Urea Derivatives of Combretastatins as Anticancer Agents\",\"authors\":\"V. Ramesh, G. Rao, B. Chakrapani, A. Chakravarthy\",\"doi\":\"10.7598/cst2018.1525\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A series of new combretastatin urea derivatives (12a-j) were synthesized by reacting of substituted aromatic isocyanates (11a-j) to the combretastatin pyrazole-amine. The synthesized derivatives 11a-j were evaluated for their cytotoxicity against four human cancer cell lines (breast, lung and ovarian). Among them, compounds 12a, 12c, 12d, 12f, 12g and 12i were showed potent anticancer activity.\",\"PeriodicalId\":10087,\"journal\":{\"name\":\"Chemical science transactions\",\"volume\":\"61 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical science transactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7598/cst2018.1525\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical science transactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/cst2018.1525","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and Biological Evaluation of Urea Derivatives of Combretastatins as Anticancer Agents
A series of new combretastatin urea derivatives (12a-j) were synthesized by reacting of substituted aromatic isocyanates (11a-j) to the combretastatin pyrazole-amine. The synthesized derivatives 11a-j were evaluated for their cytotoxicity against four human cancer cell lines (breast, lung and ovarian). Among them, compounds 12a, 12c, 12d, 12f, 12g and 12i were showed potent anticancer activity.
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