应激家庭和胰岛素受体在多囊卵巢综合征(pcos)胰岛素抵抗中的表达情况?:印度尼西亚

M. Suhron, Zakkiyatus Zainiyah
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引用次数: 22

摘要

简介:多囊卵巢综合征(PCOS)以月经紊乱(闭经/少经)、多毛、出现痤疮、脱发为特征,生化检查结果显示雄激素(睾酮)升高。本研究旨在分析马杜拉地区胰岛素抵抗型多囊卵巢综合征(PCOS)患者的家庭应激和INSR基因的表达。方法:采用病例-对照研究设计,选取Madura部落50例PCOS患者(PCOS病例)和50例健康女性(Non-PCOS)为研究对象,采用Kempe家庭压力量表(KFSI)和深度访谈法,筛选SGOT、SGPT、BUN、Creatinin和GDA,对INSR基因进行PCR和RFLP检测,并对10例样本继续测序。结果:家庭应激反应中存在孤立、自卑或抑郁的家庭平均得分为56.4分(SD=4.23)。INSR基因TT基因型为16.67%,TC基因型为63.33%,CC基因型为20.00%,对照组TT基因型为38.24%,TC基因型为44.12%,CC基因型为17.65%,病例组T基因型为48.33%,C基因型为51.67%,T基因型为56.67%,C基因型为43.33%,经病例组和对照组卡方检验,基因型和等位基因型差异无统计学意义(p值> 0.05)。结论:家庭应激反应表现为孤立、自卑、抑郁。INSR基因的表达结果在PCOS妇女和健康妇女之间无差异。由于少数民族之间的种族差异,特别是在印度尼西亚,它需要继续下去。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HOW WERE STRESS FAMILY AND INSR (INSULIN RECEPTOR) EXPRESSION IN POLYCYSTIC OVARY SYNDROME (PCOS) INSULIN RESISTANT IN MADURESE TRIBE?: INDONESIA
Introduce: Polycystic ovary syndrome (PCOS) is characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, the appearance of acne, alopecia, and biochemical examination results showed an increase in androgen (testosterone). This study aimed to analyze family stress and expression of the gene INSR in insulin-resistant polycystic ovary syndrome (PCOS) in Madura. Methods: This is an analytic observational study with a study design case-control, the sample of 50 patients (PCOS cases) and 50 healthy women (Non-PCOS) in Madura Tribe, the research instrument used Kempe Family Stress Inventory (KFSI) and using in-depth interviews, followed by screening for SGOT, SGPT, BUN, Creatinin and GDA, PCR and RFLP on the INSR gene and continued sequencing on 10 samples. Result: The results of family stress reaction family with isolation, low self-esteem or depression average score was 56.4 (SD=4.23). The gene INSR had TT genotype 16.67%, TC 63.33%, and CC 20.00%, the control group had TT genotype 38.24%, TC 44.12%, and CC 17.65%, while in the case group T allele 48.33%, C allele 51.67% and T allele control group 56.67% and C allele 43.33%, based on statistical test chi-square in case and control groups, both genotype and allele had no significant difference (P-value> 0.05). Conclusion: The results showed family stress reaction with isolation, low self-esteem or depression. The expression result of INSR gene yielded was no difference between PCOS and healthy women. It needs to be continued because of racial differences between ethnic groups, especially in Indonesia.
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