甲状腺内微量元素水平升高与女性甲状腺肿和甲状腺癌风险的关系

Z. V
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摘要

导读:年龄的增长会影响腺瘤性甲状腺肿和甲状腺癌的形成。甲状腺中特定te含量的过量或缺乏在甲状腺的甲状腺肿和癌变中起重要作用。目的:探讨正常女性甲状腺微量元素(TE)含量随年龄的变化规律。方法:从33例年龄在3.5 ~ 87岁之间的主要因外伤猝死的女性(欧洲-高加索)尸体解剖标本中随机抽取甲状腺标本。采用中子活化分析和电感耦合等离子体质谱法研究了正常女性甲状腺TEs的质量分数。组织样本被分成两部分。一个用于形态学研究,另一个用于TEs分析。结果:女性正常甲状腺Co、Cs、Fe、La、Pb、Rb、Sb、Se、Sn、Tl、Zn的质量分数在一生中有显著增加。老年人甲状腺中Co、La、Pb、Sb、Sn、Tl等致癌性或潜在致癌性TEs的含量是少女或青年妇女甲状腺中含量的5-10倍。结论:从我们的研究结果来看,老年女性甲状腺中Co、Cs、Fe、La、Pb、Rb、Sb、Se、Sn、Tl和Zn水平升高很可能会导致甲状腺肿和致癌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Elevated Levels of Some Intra-Thyroidal Trace Elements with Goiter and Cancer Risk of Female Thyroid
Introduction: Advancing age is known to influence the formation of adenomatous goiter and thyroid cancer. An excess or deficiency of specific TEs contents in thyroid can play an important role in goitro- and carcinogenesis of this gland. Objective: This study aimed to assess the variation with age of fifty trace element (TE) contents in normal female thyroid. Methods: Samples of the human thyroid were obtained from randomly selected autopsy specimens of 33 females (European- Caucasian) aged 3.5 to 87 years after a sudden death mainly from trauma. The mass fractions of TEs in normal female thyroids were investigated using neutron activation analysis and inductively coupled plasma mass spectrometry. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TEs analysis. Results: This work revealed that there is a statistically significant increase in Co, Cs, Fe, La, Pb, Rb, Sb, Se, Sn, Tl, and Zn mass fraction in the normal thyroid of female during a lifespan. Contents of such carcinogenic or potentially carcinogenic TEs as Co, La, Pb, Sb, Sn, and Tl in thyroid of seniors are 5-10 times higher than those in thyroid of girls or young women. Conclusions: From results of our study, a goitrogenic and carcinogenic effect of elevated Co, Cs, Fe, La, Pb, Rb, Sb, Se, Sn, Tl, and Zn levels in the thyroid of elderly females is shown to be a very likely consequence.
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