生长激素或IGF-1水平升高并不总是诊断肢端肥大症

IF 1.6 4区 医学 Q4 CELL BIOLOGY
Carolina Peixe , Miriam Sánchez-García , Ashley B. Grossman , Márta Korbonits , Pedro Marques
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引用次数: 3

摘要

生长激素(GH)和胰岛素样生长因子-1 (IGF-1)升高最常见的诊断是由分泌GH的垂体瘤引起的肢端肥大症。然而,由于早期或部分治疗的疾病,肢端肥大症患者的GH和IGF-1水平可能不一致,或者可能存在与肢端肥大症无关的高GH或高IGF-1的其他原因,如分析前和技术缺陷、生理环境和病理条件。应仔细评估高生长激素和正常或低血清IGF-1,或者正常生长激素与血清IGF-1升高,以避免误解肢端肥大症的活动或误诊肢端肥大症患者。我们在这里总结这些生化差异在评估躯体营养轴。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biochemical discrepancies in the evaluation of the somatotroph axis: Elevated GH or IGF-1 levels do not always diagnose acromegaly

The most frequent diagnosis underlying the finding of an elevated growth hormone (GH) and insulin-like growth factor-1 (IGF-1) is acromegaly due to a GH-secreting pituitary tumour. However, GH and IGF-1 levels can be discordant in patients with acromegaly due to early or partially treated disease, or there might be another cause of high GH or high IGF-1 unrelated to acromegaly, such as pre-analytical and technical pitfalls, physiological circumstances and pathological conditions. High GH and normal or low serum IGF-1, or alternatively, normal GH with elevated serum IGF-1, should be carefully assessed to avoid misinterpreting the activity of acromegaly or misdiagnosing a patient with acromegaly. We summarise here these biochemical discrepancies in the evaluation of the somatotroph axis.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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