作为杀菌剂活性成分的氧化铝和氧化钼纳米颗粒的生物蓄积和毒性效应评价

M. Stepankov
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引用次数: 0

摘要

介绍。氧化铝(Al2O3)和氧化钼(MoO3)纳米颗粒(NPs)具有作为杀菌剂活性组分的潜力。与此同时,科学文献中也有关于这些NPs对生物体的负面影响的信息。因此,对Al2O3和MoO3 NPs的毒性进行研究和比较分析似乎是有意义的。材料和方法。研究了Al2O3 NPs和MoO3 NPs的物理性质。在Wistar大鼠实验中,研究了多次吸入暴露的生物蓄积特性和毒性作用。结果。从粒径、形状、比表面积、总孔隙体积等参数判断,所检测的样品为纳米材料。暴露于Al2O3 NPs下,肺、脑、肝和血液中的铝浓度均较对照组显著升高;心脏、肺、脑、肾和血液中的MoO3 NPs -钼浓度。与暴露于Al2O3 NPs (ALT、AST、ALP、LDH活性、直接胆红素、尿素、肌酐浓度升高)相比,暴露于MoO3 NPs下,相对于生化参数控制(ALP、LDH活性升高、总胆红素和直接胆红素浓度升高)的负面影响范围更广。暴露于Al2O3 NPs下,肺、脑、心脏和肝脏发生病理形态学改变;暴露于肺部的MoO3 NPs下,肺、脑和肝脏的变化。然而,暴露于MoO3 NPs后的组织变化比暴露于Al2O3 NPs时的组织变化更明显。的局限性。在Wistar大鼠实验中,本研究仅涉及多次吸入暴露于Al2O3 NPs和MoO3 NPs。结论。Al2O3和MoO3 NPs在毒性动力学上的差异使我们无法从中挑选出对人类健康更危险的NPs,因此需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of bioaccumulation and toxic effect of aluminum and molybdenum oxide nanoparticles used as an active component of bactericidal agents
Introduction. Nanoparticles (NPs) of aluminum oxide (Al2O3) and molybdenum oxide (MoO3) have the potential to be used as an active component of bactericidal agents. At the same time, there is information in the scientific literature about the negative effects of these NPs on organism. Given that, it seems relevant to perform the study and comparative analysis of the toxicity of Al2O3 and MoO3 NPs. Materials and methods. We examined physical properties of Al2O3 NPs and MoO3 NPs. In an experiment on Wistar rats, peculiarities of bioaccumulation and toxic action at multiply inhalation exposure was researched. Results. The examined samples were a nanomaterial judging by such parameters as particle size, shape, surface area and total pore volume. Under exposure to Al2O3 NPs, aluminum concentrations were statistically significant increase in the lungs, brain, liver and blood relative to the control; under exposure to MoO3 NPs – molybdenum concentration in heart, lungs, brain, kidney and blood. Under exposure to MoO3 NPs, a wider range of negative effects changed relative to the control of biochemical parameters (increased activity of ALP, LDH, concentrations of total and direct bilirubin, urea, creatinine) was established than during exposure to Al2O3 NPs (increased activity of ALT, AST, ALP, LDH, concentrations direct bilirubin). Pathomorphological changes were identified in the lungs, brain, heart and liver under exposure to Al2O3 NPs; in lungs, brain and liver under exposure to MoO3 NPs in the lungs. However, tissue changes upon exposure to MoO3 NPs are more pronounced than those upon exposure to Al2O3 NPs. Limitations. The study involved only multiple inhalation exposure to Al2O3 NPs and MoO3 NPs in an experiment on Wistar rats. Conclusion. Differences in the toxicokinetics of Al2O3 and MoO3 NPs do not make it possible to single out among them those that are more dangerous for human health, and therefore additional studies are needed.
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