The effect of alpha-ketoglutarate (AKG) on the behaviour of ageing laboratory mice

Ageing is a complex physiological process characterized by a gradual decline in cell, tissue and organ function. Consequently, ageing is a major risk factor for cardiovascular disease, diabetes and neurodegenerative disorders. Altered nervous system function can lead to behavioural or psychological disorders. Recent research has shown that alpha ketoglutarate (AKG) is a key intermediate in the Krebs cycle that extends the lifespan of adult animal organisms. The objective of this study was to assess the effect of AKG on the behaviour of laboratory mice in an open field test. The Na-AKG form was found to enhance perceptual-motor exploration in the mice (expressed as the number of rearings), and at the same time to suppress anxiety-related behaviour.