休止期排尿患者的硫醇/二硫体内平衡:氧化应激在休止期排尿的发病机制中重要吗?

IF 0.1 Q4 DERMATOLOGY
Unsal Savci, M. Şahin, E. Şenel, A. Oztekin, U. Muslu, M. Sungur, S. Neşelioğlu, O. Erel
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引用次数: 4

摘要

目的:探讨休止期排气(TE)与氧化应激(OS)新指标硫醇/二硫平衡的相关性,并探讨OS在TE发病机制中的作用。方法:本研究纳入101例TE诊断患者和39例健康人。采用Erel和Neselioglu开发的自动光谱法测定血清硫醇/二硫,并对结果进行统计学比较。结果:在6个硫醇/二硫参数中,患者组与对照组天然硫醇、总硫醇、二硫、二硫/天然硫醇、二硫/总硫醇、天然硫醇/总硫醇的差异均有统计学意义(P值分别为0.042、0.044、<0.001、0.013、0.026、<0.001)。结论:基于本研究结果,可以说OS与TE的发病机制密切相关。有必要开展新的研究,以显示OS对TE发病机制的可能影响,并研究除硫醇/二硫参数外的不同OS标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thiol/disulfide homeostasis in patients with telogen effluvium: is oxidative stress important in the pathogenesis of telogen effluvium?
Objective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE. Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, <0.001, 0.013, 0.026, and < 0.001, respectively). Conclusions: Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.
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CiteScore
0.50
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