回肠etv6 - ntrk3阳性炎性肌纤维母细胞瘤1例报告及小儿肠息肉样病变鉴别诊断综述

IF 0.2
Mio Tanaka, Nanako Terada, Misa Yoshida, M. Shinkai, Yukichi Tanaka
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引用次数: 2

摘要

我们报告一例肠息肉引起肠套叠在一个2个月大的男孩。经组织学和免疫组化诊断为间变性淋巴瘤激酶(ALK)阴性炎性肌纤维母细胞瘤(IMT),逆转录-聚合酶链反应检测ETS变异6 (ETV6) -神经营养受体酪氨酸激酶3 (NTRK3)融合基因。最近,组织学上明确的alk阴性imt具有ETV6-NTRK3融合基因已被报道。据我们所知,这是第一例携带ETV6-NTRK3的肠道IMT病例。在alk阴性IMTs或具有相当高细胞密度的梭形细胞病变的鉴别诊断中,应考虑ETV6重排。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ETV6-NTRK3–Positive Inflammatory Myofibroblastic Tumor of the Ileum: Report of an Infantile Case and Review of the Differential Diagnosis of Pediatric Intestinal Polypoid Lesions
We report a case of an intestinal polyp causing intussusception in a 2-month-old boy. The resected polyp was diagnosed by histology and immunohistochemistry as an anaplastic lymphoma kinase (ALK)–negative inflammatory myofibroblastic tumor (IMT), and the ETS variant 6 (ETV6)–neurotrophic receptor tyrosine kinase 3 (NTRK3) fusion gene was detected by reverse transcription–polymerase chain reaction. Recently, histologically definitive, ALK-negative IMTs possessing the ETV6-NTRK3 fusion gene have been reported. To the best of our knowledge, this is the first case of an intestinal IMT harboring ETV6-NTRK3. In the differential diagnosis of ALK-negative IMTs or spindle cell lesions showing considerably high cellularity, ETV6 rearrangement should be considered.
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期刊介绍: Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.
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