揭示海马-丘脑-皮质模型中纺锤体和纹波动力学与突触连接之间的相关性

S. Sriram, Hayder Natiq, K. Rajagopal, Fatemeh Parastesh, S. Jafari
{"title":"揭示海马-丘脑-皮质模型中纺锤体和纹波动力学与突触连接之间的相关性","authors":"S. Sriram, Hayder Natiq, K. Rajagopal, Fatemeh Parastesh, S. Jafari","doi":"10.1142/s0218127423501092","DOIUrl":null,"url":null,"abstract":"Consolidation of new information in memory occurs through the simultaneous occurrence of sharp-wave ripples (SWR) in the hippocampus network, fast–slow spindles in the thalamus network, and up and down oscillations in the cortex network during sleep. Previous studies have investigated the influential and active role of spindles and sharp-wave ripples in memory consolidation. However, a detailed investigation of the effect of membrane voltage of neurons and synaptic connections between neurons in the cortex, hippocampus, and thalamus networks to create spindle and SWR is required. This paper studies the dynamic behaviors of a hippocampal-thalamic-cortical network as a function of synaptic connection between excitatory neurons, inhibitory neurons (in the hippocampus and cortex), reticular neurons, and thalamocortical neurons (in the thalamic network). The bifurcation diagrams of the hippocampus, cortex, and thalamus networks are obtained by varying the strengths of different synaptic connections. The power diagrams for SWR and sleep spindles are shown accordingly. The results show that variations in synaptic self-connection (and inhibitory synaptic connection) of excitatory neurons in the CA3 region, as well as synaptic connection between excitatory neurons from CA1 region to excitatory neurons (and inhibitory neurons) in the cortex network have the most significant influence on dynamical behavior of the network. Furthermore, comparing diagrams for different synaptic connections shows that SWR is formed by excitatory neurons in CA3 region of the hippocampal network, passes through CA1 region, and enters cortex network.","PeriodicalId":13688,"journal":{"name":"Int. J. Bifurc. Chaos","volume":"75 2 1","pages":"2350109:1-2350109:30"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Uncovering the Correlation Between Spindle and Ripple Dynamics and Synaptic Connections in a Hippocampal-Thalamic-Cortical Model\",\"authors\":\"S. Sriram, Hayder Natiq, K. Rajagopal, Fatemeh Parastesh, S. Jafari\",\"doi\":\"10.1142/s0218127423501092\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Consolidation of new information in memory occurs through the simultaneous occurrence of sharp-wave ripples (SWR) in the hippocampus network, fast–slow spindles in the thalamus network, and up and down oscillations in the cortex network during sleep. Previous studies have investigated the influential and active role of spindles and sharp-wave ripples in memory consolidation. However, a detailed investigation of the effect of membrane voltage of neurons and synaptic connections between neurons in the cortex, hippocampus, and thalamus networks to create spindle and SWR is required. This paper studies the dynamic behaviors of a hippocampal-thalamic-cortical network as a function of synaptic connection between excitatory neurons, inhibitory neurons (in the hippocampus and cortex), reticular neurons, and thalamocortical neurons (in the thalamic network). The bifurcation diagrams of the hippocampus, cortex, and thalamus networks are obtained by varying the strengths of different synaptic connections. The power diagrams for SWR and sleep spindles are shown accordingly. The results show that variations in synaptic self-connection (and inhibitory synaptic connection) of excitatory neurons in the CA3 region, as well as synaptic connection between excitatory neurons from CA1 region to excitatory neurons (and inhibitory neurons) in the cortex network have the most significant influence on dynamical behavior of the network. Furthermore, comparing diagrams for different synaptic connections shows that SWR is formed by excitatory neurons in CA3 region of the hippocampal network, passes through CA1 region, and enters cortex network.\",\"PeriodicalId\":13688,\"journal\":{\"name\":\"Int. J. Bifurc. Chaos\",\"volume\":\"75 2 1\",\"pages\":\"2350109:1-2350109:30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Int. J. Bifurc. Chaos\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1142/s0218127423501092\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Int. J. Bifurc. Chaos","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/s0218127423501092","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

在睡眠中,新信息在记忆中的巩固是通过海马体网络中的锐波涟漪(SWR)、丘脑网络中的快慢纺锤波和皮层网络中的上下振荡同时发生的。以往的研究已经探讨了纺锤波和尖波涟漪在记忆巩固中的积极作用。然而,需要详细研究神经元的膜电压以及皮层、海马和丘脑网络中神经元之间的突触连接对产生纺锤体和SWR的影响。本文研究了兴奋性神经元、抑制性神经元(位于海马和皮层)、网状神经元和丘脑皮质神经元(位于丘脑网络)之间突触连接的动态行为。海马体、皮层和丘脑网络的分叉图是通过改变不同突触连接的强度得到的。SWR和睡眠纺锤体的功率图如图所示。结果表明,CA3区的兴奋性神经元突触自连接(和抑制性突触连接)以及CA1区的兴奋性神经元与皮层网络中的兴奋性神经元(和抑制性神经元)之间的突触连接的变化对网络的动态行为影响最为显著。此外,通过对比不同突触连接图可知,SWR由海马网络CA3区的兴奋性神经元形成,经CA1区进入皮层网络。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Uncovering the Correlation Between Spindle and Ripple Dynamics and Synaptic Connections in a Hippocampal-Thalamic-Cortical Model
Consolidation of new information in memory occurs through the simultaneous occurrence of sharp-wave ripples (SWR) in the hippocampus network, fast–slow spindles in the thalamus network, and up and down oscillations in the cortex network during sleep. Previous studies have investigated the influential and active role of spindles and sharp-wave ripples in memory consolidation. However, a detailed investigation of the effect of membrane voltage of neurons and synaptic connections between neurons in the cortex, hippocampus, and thalamus networks to create spindle and SWR is required. This paper studies the dynamic behaviors of a hippocampal-thalamic-cortical network as a function of synaptic connection between excitatory neurons, inhibitory neurons (in the hippocampus and cortex), reticular neurons, and thalamocortical neurons (in the thalamic network). The bifurcation diagrams of the hippocampus, cortex, and thalamus networks are obtained by varying the strengths of different synaptic connections. The power diagrams for SWR and sleep spindles are shown accordingly. The results show that variations in synaptic self-connection (and inhibitory synaptic connection) of excitatory neurons in the CA3 region, as well as synaptic connection between excitatory neurons from CA1 region to excitatory neurons (and inhibitory neurons) in the cortex network have the most significant influence on dynamical behavior of the network. Furthermore, comparing diagrams for different synaptic connections shows that SWR is formed by excitatory neurons in CA3 region of the hippocampal network, passes through CA1 region, and enters cortex network.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信