石棉相关肺部疾病:简要更新

S. Jargin
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引用次数: 0

摘要

考虑到以往在工作场所接触石棉的职业历史,对接触石棉的健康风险进行了评估。线性无阈值(LNT)模型已被应用,尽管其相关性尚未得到证实。纤维常在死者的肺和胸膜中发现。纤维的发现并不能证明某种疾病是由石棉引起的。有理由认为,在石棉工人中对间皮瘤和其他石棉相关疾病进行有针对性的搜索导致了检出率的提高。恶性间皮瘤的组织学和免疫组织化学特征与其他癌症部分重叠,这可能导致暴露人群的过度诊断。本文就恶性胸膜间皮瘤的病因、鉴别诊断及不同石棉类型的致癌性差异作一简要讨论。笔者认为,目前一些国家的规定过于严格,应该在独立研究的基础上重新考虑。获得可靠信息的最有希望的方法是终身生物检测。可以合理地假设,不使用含石棉的制动器、防火材料、绝缘材料等会增加火灾、交通事故和武装冲突造成的伤害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Asbestos-related Lung Diseases: A Brief Update
Health risks from asbestos exposures have been evaluated, considering past professional histories when exposures at workplaces were higher than today. A linear no-threshold (LNT) model has been applied, although its relevance is unproven. Fibers are often found in the lungs and pleura of deceased people. Fiber findings do not prove that a disease is caused by asbestos. It is reasonable to assume that a targeted search for mesothelioma and other asbestos-related conditions in asbestos workers resulted in an increased detection rate. Histological and immunohistochemical characteristics of malignant mesothelioma partly overlap with other cancers, which may contribute to the overdiagnosis in exposed populations. The etiology and differential diagnosis of malignant pleural mesothelioma as well as differences in carcinogenicity between different asbestos types are briefly discussed here. In the author’s opinion, current regulations applied in some countries are excessive and should be reconsidered based on independent research. The most promising way to obtain reliable information would be through lifelong bioassays. It can be reasonably assumed that the non-use of asbestos-containing brakes, fireproofing, insulation, etc. increases the harm caused by fires, traffic accidents, and armed conflicts.
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