基于单片多晶硅纳米线CMOS工艺的全集成乙型肝炎病毒DNA检测SoC

2012 Symposium on VLSI Circuits (VLSIC) Pub Date : 2012-06-13 DOI:10.1109/VLSIC.2012.6243821

Che-Wei Huang, Yu-Jie Huang, Pei-Wen Yen, Hsiao-Ting Hsueh, Chia-Yi Lin, Min-Cheng Chen, C. Ho, Fu-Liang Yang, H. Tsai, H. Liao, Y. Juang, Chorng-Kuang Wang, Chih-Ting Lin, Shey-Shi Lu

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引用次数: 11

摘要

基于多晶硅纳米线(poly-Si NW)的生物传感器首次与无线采集电路集成在标准CMOS SoC中。为了提高检测质量，实现了一种低噪声、高CMRR、轨对轨输入范围的斩波数模模拟前端。还包括额外的温度传感器，以补偿生物传感器的温度漂移。结果表明，检测限低至10fM。还证明了区分碱基对错配dna的能力。

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A fully integrated hepatitis B virus DNA detection SoC based on monolithic polysilicon nanowire CMOS process

Polysilicon nanowire (poly-Si NW) based biosensor is integrated with the wireless acquisition circuits in a standard CMOS SoC for the first time. To improve detection quality, a chopper DDA-based analog front-end with features of low noise, high CMRR, and rail-to-rail input range is implemented. Additional temperature sensor is also included to compensate temperature drift of the biosensor. The results indicate that the detection limit is as low as 10fM. The capability to distinguish one base-pair mismatched DNAs is also demonstrated.

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2012 Symposium on VLSI Circuits (VLSIC)

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