Problems of antibiotic resistance in the modern world

Aim. Study the rate of spread of resistance of pathogenic microflora to a number of antibacterial drugs used in the therapeutic and preventive scheme at one of the operating poultry farms in the south of Russia, depending on the duration of the period of use. Materials and Methods. Veterinary and preventive measures were carried out according to the plan of antiepizootic measures. Antibacterial preparations were used for prophylactic antibacterial treatment of broiler chickens: Enrofloxacin – the first preventive treatment of chickens by drinking at the age of 1-5 days, Colistin – the second preventive treatment of broiler at the age of 20-25 days. Results. Antibacterial drugs Enrofloxacin, Colistin, which in the first two rounds showed their good effectiveness in the prevention of pathogenic microflora of broiler chickens, during the period of use in the therapeutic and prophylactic scheme on the tested broiler chickens of the third round of fattening, lost their effectiveness due to mutations and the adaptability of the microbial background to this type of antibiotics, which also affected the safety of livestock and production indicators according to the results of the round. Conclusion. The resistance of pathogenic microflora, most often manifested when fattening broilers on an industrial scale with more than one use of the same antibacterial drugs, develops acquired resistance as a result of contact of a microorganism with an antimicrobial agent due to the occurrence of mutations or due to horizontal transfer of resistance genes.