锌在甲状腺激素的合成和代谢过程中的作用

Екатерина Анатольевна Трошина, Евгения Семёновна Сенюшкина
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引用次数: 1

摘要

世界上约有三分之一的人口缺乏一种或多种微量营养素,其中最常见的缺乏碘、铁、锌、维生素A和叶酸。缺乏一种或多种必需维生素和矿物质通常是由于感染性和炎症性疾病造成的营养不良和/或微量营养素吸收不足造成的。有可能某些微量元素的缺乏反过来又会加重碘缺乏并导致甲状腺功能障碍。关于人体内碘、硒、铁、锌的含量与甲状腺激素水平之间的关系,有一些假设。锌是所有生物体内重要的微量元素,参与细胞的许多生化过程,包括细胞分化和分裂、细胞生长、细胞转运、转录、蛋白质合成、RNA和DNA合成以及DNA复制。它作为抗氧化剂的作用和参与先天(T, NK和NKT细胞)和适应性免疫(抗炎细胞因子)的功能是非常重要的。本文就锌在甲状腺激素合成和代谢中的作用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Роль цинка в процессах синтеза и метаболизма гормонов щитовидной железы
About one third of the world’s population is deficient in one or more micronutrients, with the most common deficiencies in iodine, iron, zinc, vitamin A and folate. Deficiency of one or more essential vitamins and minerals is usually the result of poor nutrition and / or insufficient absorption of micronutrients as a result of infectious and inflammatory diseases. It is possible that the deficiency of certain trace elements, in turn, can aggravate iodine deficiency and contribute to dysfunction of the thyroid gland. There are assumptions about the relationship between the content of iodine, selenium, iron, zinc in the human body and the level of thyroid hormones. Zinc is a vital trace element for all living organisms, participating in many biochemical processes in cells, including cell differentiation and division, its growth, cell transport, transcription, protein synthesis, RNA and DNA synthesis, and DNA replication. Its role as an antioxidant and participation in the functioning of both innate (T, NK and NKT cells) and adaptive immunity (anti-inflammatory cytokines) are very important. This review will consider the role of zinc in the synthesis and metabolism of thyroid hormones.
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