一种用于预防假体关节感染的金属植入物的可生物降解和抗菌聚合物涂层

Tiancheng Luo, M. Wylie, C. McCoy
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引用次数: 0

摘要

该项目的目的是通过喷枪在矫形植入物上生产含有抗生素的聚乳酸-羟基乙酸(PLGA)聚合物薄膜,以解决假体关节感染(PJIs)。它涵盖了喷枪喷涂技术的发展,聚合物和抗生素的选择和评估,样品表征和抗菌研究。初步结果令人鼓舞,因为PLGA涂层表现出持续的药物释放模式和对致病病原体的抗菌能力。此外,这些PLGA涂层还具有在4周内快速降解的特性,为骨整合提供了有利的条件。此外,需要对最终涂层进行细胞毒性评估,以确保生物相容性,并确定每种涂层对骨整合的影响。最后,开发更经济、更适合大规模生产的替代涂层技术可能是未来研究的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A biodegradable and antimicrobial polymer coating for metal implants for the prevention of prosthetic joint infection
The aim of this project is to produce antibiotic-loaded poly (lactic-co-glycolic acid) (PLGA) polymer films by airbrush onto orthopaedic implants to address prosthetic joint infections (PJIs). It covered the development of an airbrush spray-coating technique, the selection and assessment of polymers and antibiotics, sample characterisation and antibacterial studies. The initial results are encouraging as the PLGA coatings exhibited a sustained drug release pattern and antibacterial ability against causative pathogens. Moreover, these PLGA coatings also possessed rapid degradation within 4 weeks which could provide favourable conditions for osseointegration. Furthermore, cytotoxicity assessment of final coatings will need to be conducted to ensure biocompatibility, as well as to determine the effect of each coating on osseointegration. Finally, the development of alternative coating techniques which are more cost-effective and suitable for large scale production might be the direction of future research. 
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