METHIMAZOLE.

Evidence Quality Evidence Type A Good evidence to support a recommendation for use B Moderate evidence to support a recommendation for use 1 Species-specific evidence from at least one large randomized and controlled trial (RCT) or multiple small RCTs C Insufficient evidence to support a recommendation for use D Moderate evidence to support a recommendation against use E Good evidence to support a recommendation against use 2 Species-specific evidence from a small RCT, disease models, large case studies, pharmacokinetic studies using surrogate endpoints, or evidence from well-designed trials in a different species that is considered appropriate for comparison 3 Dramatic results from either well-designed, species-specific trials without controls or small case studies 4 Pharmacokinetic studies without surrogate endpoints 5 In vitro studies 6 Opinions of respected authorities on the basis of clinical experience or reports of expert committees