中心复合旋转式设计优化阿拉伯木聚糖基替扎尼定口服膜

Q2 Materials Science
M. Zaman, Muhammad Hanif, M. A. Khan
{"title":"中心复合旋转式设计优化阿拉伯木聚糖基替扎尼定口服膜","authors":"M. Zaman, Muhammad Hanif, M. A. Khan","doi":"10.1080/03602559.2017.1324575","DOIUrl":null,"url":null,"abstract":"ABSTRACT In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics. GRAPHICAL ABSTRACT","PeriodicalId":20629,"journal":{"name":"Polymer-Plastics Technology and Engineering","volume":"12 1","pages":"471 - 483"},"PeriodicalIF":0.0000,"publicationDate":"2018-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Arabinoxylan-Based Mucoadhesive Oral Films of Tizanidine HCL Designed and Optimized Using Central Composite Rotatable Design\",\"authors\":\"M. Zaman, Muhammad Hanif, M. A. Khan\",\"doi\":\"10.1080/03602559.2017.1324575\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACT In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics. GRAPHICAL ABSTRACT\",\"PeriodicalId\":20629,\"journal\":{\"name\":\"Polymer-Plastics Technology and Engineering\",\"volume\":\"12 1\",\"pages\":\"471 - 483\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-03-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polymer-Plastics Technology and Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/03602559.2017.1324575\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Materials Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer-Plastics Technology and Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/03602559.2017.1324575","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Materials Science","Score":null,"Total":0}
引用次数: 10

摘要

摘要:本研究从ispaghula壳中提取天然药用辅料阿拉伯木聚糖,制备盐酸替扎尼定的控释黏附口服膜。以阿拉伯木聚糖(X1)和甘油(X2)为变量,采用中心复合旋转设计法对膜的配方进行设计和优化。对制备的膜进行成分的化学相容性、表面形貌、机械强度、体外药物释放、体外药物渗透和体外黏附强度的评价。结果表明,所选择的原料是相容的,能够生产出具有理想特性的薄膜。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Arabinoxylan-Based Mucoadhesive Oral Films of Tizanidine HCL Designed and Optimized Using Central Composite Rotatable Design
ABSTRACT In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics. GRAPHICAL ABSTRACT
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Polymer-Plastics Technology and Engineering
Polymer-Plastics Technology and Engineering 工程技术-高分子科学
CiteScore
1.71
自引率
0.00%
发文量
0
审稿时长
4 months
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信