中心复合旋转式设计优化阿拉伯木聚糖基替扎尼定口服膜

Q2 Materials Science

Polymer-Plastics Technology and Engineering Pub Date : 2018-03-24 DOI:10.1080/03602559.2017.1324575

M. Zaman, Muhammad Hanif, M. A. Khan

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引用次数: 10

摘要

摘要:本研究从ispaghula壳中提取天然药用辅料阿拉伯木聚糖，制备盐酸替扎尼定的控释黏附口服膜。以阿拉伯木聚糖(X1)和甘油(X2)为变量，采用中心复合旋转设计法对膜的配方进行设计和优化。对制备的膜进行成分的化学相容性、表面形貌、机械强度、体外药物释放、体外药物渗透和体外黏附强度的评价。结果表明，所选择的原料是相容的，能够生产出具有理想特性的薄膜。图形抽象

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Arabinoxylan-Based Mucoadhesive Oral Films of Tizanidine HCL Designed and Optimized Using Central Composite Rotatable Design

ABSTRACT In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics. GRAPHICAL ABSTRACT

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来源期刊

Polymer-Plastics Technology and Engineering 工程技术-高分子科学

CiteScore

1.71

自引率

0.00%

发文量

审稿时长

4 months