关于大鼠长期吸入暴露氧化镍纳米颗粒的阈浓度

B. Katsnelson, I. N. Chernyshov, S. Solovyeva, I. Minigalieva, V. Gurvich, I. E. Valamina, O. Makeyev, R. R. Sahautdinova, L. Privalova, A. E. Tsaregorodtseva, A. V. Korotkov, E. Shuman, V. Panov, M. Sutunkova
{"title":"关于大鼠长期吸入暴露氧化镍纳米颗粒的阈浓度","authors":"B. Katsnelson, I. N. Chernyshov, S. Solovyeva, I. Minigalieva, V. Gurvich, I. E. Valamina, O. Makeyev, R. R. Sahautdinova, L. Privalova, A. E. Tsaregorodtseva, A. V. Korotkov, E. Shuman, V. Panov, M. Sutunkova","doi":"10.36946/0869-7922-2021-29-5-34-42","DOIUrl":null,"url":null,"abstract":"Introduction. Nickel oxide nanoparticles are of interest for toxicological science, not only as engineered nanoparticles, producing for industrial and scientific needs, but also as spontaneous pollutants of the atmosphere and the working area in industrial processes related to metallurgy and welding. Materials and methods. Rats were exposed to nickel-oxide aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 hours at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Results. Of the several dozen examined parameters, only a few statistically significant manifestations associated with the reaction of the deep airways to inhaled nanoparticles were noted. However, in the biochemical and morphometric parameters of the lungs, even at the longest periods of exposure, the intergroup differences were insignificant. At the same time, even from the first weeks of the exposure period, genotoxic and allergic indices shifts are detected. Conclusion. For most of the evaluated effects, this level of exposure to nickel oxide nanoparticles may be considered as close to LOAEL, or even to NOAEL. However, according to some indicators, there are effects that suggest a non-threshold nature.","PeriodicalId":23128,"journal":{"name":"Toxicological Review","volume":"232 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"About the threshold concentration of nickel oxide nanoparticles in long-term inhalation exposure of rats\",\"authors\":\"B. Katsnelson, I. N. Chernyshov, S. Solovyeva, I. Minigalieva, V. Gurvich, I. E. Valamina, O. Makeyev, R. R. Sahautdinova, L. Privalova, A. E. Tsaregorodtseva, A. V. Korotkov, E. Shuman, V. Panov, M. Sutunkova\",\"doi\":\"10.36946/0869-7922-2021-29-5-34-42\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction. Nickel oxide nanoparticles are of interest for toxicological science, not only as engineered nanoparticles, producing for industrial and scientific needs, but also as spontaneous pollutants of the atmosphere and the working area in industrial processes related to metallurgy and welding. Materials and methods. Rats were exposed to nickel-oxide aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 hours at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Results. Of the several dozen examined parameters, only a few statistically significant manifestations associated with the reaction of the deep airways to inhaled nanoparticles were noted. However, in the biochemical and morphometric parameters of the lungs, even at the longest periods of exposure, the intergroup differences were insignificant. At the same time, even from the first weeks of the exposure period, genotoxic and allergic indices shifts are detected. Conclusion. For most of the evaluated effects, this level of exposure to nickel oxide nanoparticles may be considered as close to LOAEL, or even to NOAEL. However, according to some indicators, there are effects that suggest a non-threshold nature.\",\"PeriodicalId\":23128,\"journal\":{\"name\":\"Toxicological Review\",\"volume\":\"232 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicological Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36946/0869-7922-2021-29-5-34-42\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicological Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36946/0869-7922-2021-29-5-34-42","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

介绍。氧化镍纳米颗粒是毒理学研究的兴趣所在,它不仅是为工业和科学需要而生产的工程纳米颗粒,而且是与冶金和焊接有关的工业过程中大气和工作区域的自发污染物。材料和方法。大鼠在“仅鼻子”吸入装置中暴露于浓度为2.4±0.4 μ g/m3的氧化镍气溶胶中,每次4小时,每周5次,总时间为2周至6个月。结果。在几十个被检查的参数中,只有少数与吸入纳米颗粒的深气道反应相关的统计学显著表现被注意到。然而,在肺部的生化和形态计量参数中,即使在最长的暴露时间,组间差异也不显著。同时,即使从接触期的头几周开始,也可检测到遗传毒性和过敏指数的变化。结论。对于大多数已评估的影响,这种暴露于氧化镍纳米颗粒的水平可被认为接近低ael,甚至接近无ael。然而,根据一些指标,有些影响表明非阈值性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
About the threshold concentration of nickel oxide nanoparticles in long-term inhalation exposure of rats
Introduction. Nickel oxide nanoparticles are of interest for toxicological science, not only as engineered nanoparticles, producing for industrial and scientific needs, but also as spontaneous pollutants of the atmosphere and the working area in industrial processes related to metallurgy and welding. Materials and methods. Rats were exposed to nickel-oxide aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 hours at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Results. Of the several dozen examined parameters, only a few statistically significant manifestations associated with the reaction of the deep airways to inhaled nanoparticles were noted. However, in the biochemical and morphometric parameters of the lungs, even at the longest periods of exposure, the intergroup differences were insignificant. At the same time, even from the first weeks of the exposure period, genotoxic and allergic indices shifts are detected. Conclusion. For most of the evaluated effects, this level of exposure to nickel oxide nanoparticles may be considered as close to LOAEL, or even to NOAEL. However, according to some indicators, there are effects that suggest a non-threshold nature.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信