Simulation and optimisation of integrated bioprocesses: a case study

Biotech companies need to reduce time to market and to raise the efficiency of processing in order to lower costs. This paper presents results of the application of computer-based simulations for the rapid formulation of integrated bioprocesses designs and demonstrates the use of simulations to explore the nature and impact of the interactions that exist in a typical bioprocess. An approach for the optimisation of such integrated bioprocesses is presented. Data from a continuous fermentation, with models for cell harvesting, cell disruption and cell debris removal, verified by comparison with pilot-scale data, have been integrated and used to demonstrate the consequences of different process designs and operating decisions on the resulting process performance.