本中心小儿肝移植的长期随访结果

E. Karakaya, A. Akdur, H. E. Ayvazoğlu Soy, F. Özçay, S. Yıldırım, A. Sezgin, A. Torgay, G. Moray, M. Haberal
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引用次数: 0

摘要

治疗不可逆肝损伤和慢性肝病的唯一方法是肝移植(LT)。目的:确定本中心儿童肝移植受者的长期随访结果、肝移植功能和生存率。材料和方法。所有在1990年3月15日至2022年8月11日期间接受肝移植的儿科患者都被纳入我们的研究。评估儿童肝移植受者的人口统计学特征、术前临床特征、肝移植适应症、术后早期和晚期并发症、生存率和长期预后。结果。在1990年3月15日至2022年8月11日期间,我们进行了341例儿科LTs(307例来自在世的亲属供体,34例来自已故供体)。肝移植最常见的适应症是胆道闭锁。肝静脉3例,门静脉5例,肝动脉并发症54例。胆道狭窄62例,胆漏54例。总5年生存率为84.1%,10年生存率为77.7%。结论。根据本中心进行的儿童肝移植的长期结果,肝移植是终末期肝病和不可逆肝损害的儿童患者的成功治疗选择。患者的生存率也令人满意。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-term follow-up results of pediatric liver transplants at our center
The only curative treatment for irreversible liver damage and chronic liver disease is liver transplantation (LT). Objectives: to determine long‑term follow‑up results, liver graft functions, and survival rates of pediatric LT recipients at our center. Materials and methods. All pediatric LT recipients performed between March 15, 1990 and August 11, 2022 were included in our study. Demographic characteristics, preoperative clinical features, LT indications, early and late postoperative complications, survival rates, and long‑term outcomes of pediatric LT recipients were evaluated. Results. Between March 15, 1990, and August 11, 2022, we performed 341 pediatric LTs (307 from living related donors and 34 from deceased donors). The most common indication for LT was biliary atresia. There were 3 hepatic vein, 5 portal vein, and 54 hepatic artery complications. Biliary stenosis was observed in 62 patients, and biliary leakage was observed in 54 patients. The overall five‑year survival rate was 84.1 %, and the 10‑year survival rate was 77.7 %. Conclusions. According to the long‑term outcomes of pediatric liver transplants performed in our center, liver transplantation is a successful treatment option for pediatric patients with end‑stage liver disease and irreversible liver damage. The patients’ survival rates are also satisfactory.  
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