α硫辛酸对慢性不可预测轻度应激大鼠的抗抑郁作用:神经递质和5HT3受体的推测作用

Likhit Akotkar, Urmila Aswar, R. Patil, Dileep Kumar, M. Aswar, Jyoti Pandey, S. Gurav
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引用次数: 0

摘要

抑郁症是一种以情绪和认知改变为特征的神经精神疾病。α硫辛酸(ALA)是一种有效的天然抗氧化剂,具有神经保护作用。然而,其抗抑郁活性及其对慢性不可预测轻度应激(CUMS)大鼠的作用机制有待进一步研究。老鼠被分成六组。ⅰ组对照(无应激)、ⅱ组- CUMS、ⅲ组-氟西汀(FLX) (50 mg/kg, p.o)、ⅳ组、ⅴ组和ⅵ组分别用ALA(50、100、200 mg/kg, p.o)处理。除1组外,其余各组均于第1天至第42天进行CUMS +处理。在第0天、第21天、第42天分别进行体重、蔗糖偏好试验(SPT)、Morris水迷宫试验(MWM)、常驻闯入者试验(RIT)和大理石掩埋试验(MBT),最后42天和第43天分别进行强迫游泳试验(FST)。处死大鼠进行生化和组织病理学评价。ALA显著改善行为功能,增强抗氧化能力,减少脂质过氧化,恢复单胺,保护CA3神经元。此外,对接研究显示ALA与5HT3受体的强结合。该研究表明,ALA可能通过恢复单胺和调节5HT3受体而表现出抗抑郁作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antidepressant Effect of Alpha Lipoic Acid in Rats Exposed to Chronic Unpredictable Mild Stress: Putative Role of Neurotransmitters and 5HT3 Receptor
Depression is a neuropsychiatric disorder characterized by altered emotion and cognition. Alpha lipoic acid (ALA) is a potent natural antioxidant and exhibits neuroprotective effects. However, its antidepressant activity and its mechanism of action in rats exposed to chronic unpredictable mild stress (CUMS) need to be evaluated. The rats were divided into six groups. Group, I vehicle control (without stress), II- CUMS, III- fluoxetine (FLX) (50 mg/kg p.o.), IV, V, and VI were treated with ALA (50, 100, 200 mg/kg, p.o.), respectively. All the groups, except I, were subjected to CUMS + treatments from day 1 to day 42. Body weight and behavioral parameters like sucrose preference test (SPT), Morris water maze (MWM), resident intruder test (RIT), and marble-burying test (MBT) were performed on day 0, day 21, and day 42, and forced swim test (FST) on last day 42 and 43 only. The rats were further sacrificed for biochemical and histopathological evaluation. ALA significantly improved behavioral function, increased antioxidant strength, reduced lipid peroxidation, restored monoamines, and protected CA3 neurons. Further, docking studies revealed strong binding of ALA on the 5HT3 receptor. The study demonstrates that ALA might be exhibiting antidepressant effects in part by restoring monoamines and modulating the 5HT3 receptor.
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