t型Ca2+通道和局部血流的自动调节

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Channels Pub Date : 2017-01-05 DOI:10.1080/19336950.2016.1273997

L. Jensen, M. Nielsen, M. Salomonsson, C. Sørensen

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引用次数: 10

摘要

l型电压门控Ca2+通道被认为是肌源性反应中钙内流的主要来源。然而，许多血管床也表达t型电压门控Ca2+通道。最近的研究表明，这些通道也可能在自动调节中发挥作用。在低压(40-80 mmHg)下，t型通道影响大脑和肠系膜血管床的肌生成反应。t型通道似乎也参与了骨骼肌的自动调节。本文综述了t型电压门控Ca2+通道在几种不同血管床的自动调节中的表达和作用。缺乏特定的药理学抑制剂一直是该领域的一个巨大挑战。现在，该研究得到了基因修饰模型的加强，如缺乏t型电压门控Ca2+通道(CaV3.1和CaV3.2)表达的小鼠。希望这些新工具将有助于进一步阐明电压门控t型Ca2+通道在自动调节和血管功能中的作用。

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T-type Ca2+ channels and autoregulation of local blood flow

ABSTRACT L-type voltage gated Ca2+ channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca2+ channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40–80 mmHg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca2+ channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca2+ channels (CaV3.1 and CaV3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca2+ channels in autoregulation and vascular function.

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来源期刊

Channels 生物-生化与分子生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Channels is an open access journal for all aspects of ion channel research. The journal publishes high quality papers that shed new light on ion channel and ion transporter/exchanger function, structure, biophysics, pharmacology, and regulation in health and disease. Channels welcomes interdisciplinary approaches that address ion channel physiology in areas such as neuroscience, cardiovascular sciences, cancer research, endocrinology, and gastroenterology. Our aim is to foster communication among the ion channel and transporter communities and facilitate the advancement of the field.