6-芳基氨基-嘧啶-2,4(1h, 3h)-二酮系列内源性干扰素诱导剂:从设计到实践

Bulletin of the Saint Petersburg State Institute of Technology (Technical University) Pub Date : 2022-01-01 DOI:10.36807/1998-9849-2022-63-89-51-57

Victor I. Krutikov, A. Erkin, Viktor V. Tetz, I. V. Klaptyuk

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引用次数: 0

摘要

以6-氨基尿嘧啶为原料，经转氨化反应合成了一系列6-芳基氨基嘧啶-2,4(1H,3H)二酮。目标化合物中，3 -(2,6-二氧基-1,2,3,6-四氢嘧啶-4-基)氨基苯甲酸甲酯被证明是一种有效的内源性干扰素诱导剂。在随后的生物评估和专利程序中，该酯被授予ImmuVag国际非专利名称。

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INDUCERS OF ENDOGENOUS INTERFERON IN THE SERIES OF 6-ARYLAMINO-PYRIMIDINE-2,4(1H,3H)-DIONES: FROM DESIGN TO PRACTICE

A series of 6-arylaminopyrimidine-2,4(1H,3H)-diones were synthesized via transamination of 6-aminouracil. Among the target compounds, 3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)aminobenzoic acid methyl ester proved to be an effective endogenous interferon inducer. During biological evaluation followed by a patenting procedure, the ester was assigned the ImmuVag international nonproprietary name.

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Bulletin of the Saint Petersburg State Institute of Technology (Technical University)

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