米索前列醇治疗早期妊娠丢失的安全性和有效性:一项非随机临床试验

Journal of National Institute of Neurosciences Bangladesh Pub Date : 2023-01-15 DOI:10.3329/jninb.v8i2.63751

Rabeya Parvin, S. Nargis, Most Afroza Sarkar, Khaledun Nessa, Runa Parvin, R. Khanam

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On admission all women were received a vaginal administration of 800 μg misoprostol by digital insertion into the posterior fornix through a speculum (4 tablets of 200 μg misoprostol). The interval between administration of misoprostol and expulsion of product of conception was recorded. After 7 days (8th day) they were instructed to come to the hospital to see the completeness of expulsion of product of conception by ultrasonography. If sonography shows incomplete expulsion then surgical evacuation was done. Every woman were advised to come for follow-up on 15th day. Results: A total of 200 women with first-trimester pregnancy loss were non-randomly assigned to give treatment with misoprostol. The mean with the SD of the study population was 24.95±4.17 years. 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引用次数: 0

摘要

背景:早期妊娠流产的处理对妇女的生命安全至关重要。目的:观察米索前列醇治疗早孕流产的安全性和有效性。方法:这项非随机临床试验于2007年1月至2007年12月在孟加拉国Bogra的Shaheed Ziaur Rahman医学院医院的妇产科进行，为期12个月。在研究期间，选择符合选择标准的早期妊娠流产妇女作为研究人群。入院时，所有女性均经阴道后穹窿指插入米索前列醇800 μg(米索前列醇4片200 μg)。记录米索前列醇给药至排出妊娠产物的时间间隔。7天后(第8天)到医院超声检查受精卵排出情况。如果超声显示不完全排出，则进行手术清除。建议每位妇女在第15天来随访。结果:共有200名早期妊娠失败的妇女被非随机分配给米索前列醇治疗。研究人群的SD平均值为24.95±4.17岁。大多数病例在使用米索前列醇24小时内发生排尿，142例(71.0%)在48小时内完成排尿，168例(84.0%)在7天内完成排尿，200例中170例(85.0%)完成排尿。首次给药后完全排出142例(71.0%)，未完全排出58例(29.0%)。第二次给药后(85.0%)患者完全排出，30例(15.0%)患者完全排出，需要手术排出。分析结果有统计学意义(P<0.05)。阴道米索前列醇治疗似乎耐受性良好。只有少数人有轻微的副作用。约190例(95.0%)不需要输血。结论:米索前列醇治疗早孕流产效果好，不良事件少。孟加拉国国家神经科学研究所杂志，2022年7月;8(2):152-156

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Safety and Efficacy of Misoprostol for the Management of Early Pregnancy Loss: A Non-Randomized Clinical Trial

Background: Management of early pregnancy loss is very crucial for the safety of women. Objective: The purpose of the present study was to see the safety and efficacy of misoprostol for the management of early pregnancy loss. Methodology: This non-randomized clinical trial was conducted in the Department of Obstetrics and Gynaecology in Shaheed Ziaur Rahman Medical College Hospital, Bogra, Bangladesh from January 2007 to December 2007 for a period of 12 months. Women with early pregnancy loss who were fulfilling the selection criteria were selected as the study population during the study period. On admission all women were received a vaginal administration of 800 μg misoprostol by digital insertion into the posterior fornix through a speculum (4 tablets of 200 μg misoprostol). The interval between administration of misoprostol and expulsion of product of conception was recorded. After 7 days (8th day) they were instructed to come to the hospital to see the completeness of expulsion of product of conception by ultrasonography. If sonography shows incomplete expulsion then surgical evacuation was done. Every woman were advised to come for follow-up on 15th day. Results: A total of 200 women with first-trimester pregnancy loss were non-randomly assigned to give treatment with misoprostol. The mean with the SD of the study population was 24.95±4.17 years. In most cases expulsion occurred within 24 hours of application of misoprostol, 142(71.0%) cases completed expulsion within 48 hours, 168(84.0%) cases within 7 days, 170(85.0%) cases out of 200 cases completed expulsion occurred. Complete evacuation after the first dose was in 142(71.0%) cases and remained incomplete was 58(29.0%) cases. After administration of the second dose (85.0%) complete evacuation occurred and 30(15.0%) cases remained complete that needed surgical evacuation. Analysis was reveled statistically significant (P<0.05). Vaginal misoprostol treatment appeared to be well tolerated. Only few percent shows mild side effects. About 190(95.0%) cases required no blood transfusion. Conclusion: In conclusion the efficacy of misoprostol for the management of early pregnancy loss gives a good results with minimum adverse events. Journal of National Institute of Neurosciences Bangladesh, July 2022;8(2):152-156

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Journal of National Institute of Neurosciences Bangladesh

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