缺血性脑卒中患者缺氧诱导因子-1α与炎症标志物的关系

Q4 Medicine
L. Pivovarova, I. Voznyuk, I. V. Osipova, O. Ariskina, E. A. Gogoleva, M. V. Prokhorova, N. G. Karpova
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引用次数: 0

摘要

缺血性中风是由于局部血液循环障碍和脑组织缺氧而发生的。缺氧诱导因子-1α (Hypoxia-inducible factor-1α, HIF-1α)参与组织氧水平的调节,在脑卒中的病理生理中发挥重要作用,包括神经元存活、神经炎症、血管生成、葡萄糖代谢、血脑屏障通透性,并在is预后中发挥重要作用。本研究的目的是确定IS急性期血液中HIF-1α水平与神经功能缺损程度及疾病结局之间的关系。我们检查了58例73岁(67-81)的IS患者。患者分为出院组和死亡组。测定患者入院时、发病第3天和第10天脑卒中严重程度(NIHSS)、神经功能缺损、合并症指数、HIF-1α、p53蛋白、白细胞介素-6、胱抑素C、CRP、肌酐、血液学参数。入院时血液中HIF-1α水平低于对照组,并持续降低至第10天。第10天测定HIF-1α与神经功能缺损、合并症指数和疾病结局的关系。我们观察到HIF-1α与红细胞、血红蛋白和红细胞压积的含量呈反馈关系,这可以看作是混合缺氧的血液成分的反映。在死亡患者中,检测到胱抑素C血药浓度升高,这与HIF-1α浓度有关。在观察IS的所有时期,胱抑素C、肌酐和CRP水平之间的相关性被注意到。这些结果可能表明内皮细胞功能障碍,炎症与缺氧相关。第10天血HIF-1α水平对IS预后的预测意义AUC = 0.900。急性期血液中HIF-1α水平与IS的严重程度和疾病结局相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke
Ischemic stroke (IS) occurs as a result of local disturbance of hemocirculation and hypoxia in the brain tissue. Hypoxia-inducible factor-1α (HIF-1α), which is involved in the regulation of tissue oxygen levels, plays an important role in the pathophysiology of stroke, including neuronal survival, neuroinflammation, angiogenesis, glucose metabolism, blood-brain barrier permeability, and is important in IS outcomes. The purpose of the study was to determine the relationship between blood levels of HIF-1α and the degree of neurological deficit in the acute period of IS and the outcome of the disease. We examined 58 people with IS aged 73 (67-81) years. Patients were divided into two groups – discharged and dead. The severity of stroke (NIHSS), neurological deficit, comorbidity index, blood levels of HIF-1α, p53 protein, interleukin-6, cystatin C, CRP, creatinine, hematological parameters were determined at admission, on days 3 and 10 of the disease. At admission the blood levels of HIF-1α was lower than in the comparison group and remained reduced until the 10th day. On day 10 the association of HIF-1α with neurological deficit, comorbidity index and disease outcome was determined. We observed a feedback of HIF-1α with the content of erythrocytes, hemoglobin and hematocrit, which can be regarded as a reflection of the hemic component of mixed hypoxia. In dead patients, an increased blood level of cystatin C was detected, which was associated with HIF-1α concentrations. In all periods of observation of IS, a correlation between cystatin C and creatinine and CRP levels was noted. These results may indicate dysfunction of endotheliocytes, inflammation associated with hypoxia in IS. The prognostic significance of the blood level of HIF-1α on the 10th day for the outcome of IS was AUC = 0.900. Blood levels of HIF-1α in the acute period was associated with the severity of IS and the outcome of the disease.
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来源期刊
Medical Immunology (Russia)
Medical Immunology (Russia) Medicine-Immunology and Allergy
CiteScore
0.70
自引率
0.00%
发文量
88
审稿时长
12 weeks
期刊介绍: The journal mission is to promote scientific achievements in fundamental and applied immunology to various medical fields, the publication of reviews, lectures, essays by leading domestic and foreign experts in the field of fundamental and experimental immunology, clinical immunology, allergology, immunodiagnostics and immunotherapy of infectious, allergy, autoimmune diseases and cancer.
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