马驹角状肢体畸形的治疗

Joerg A. Auer Dr Med Vet, MS, Dipl ACVS, ECVS , Brigitte von Rechenberg Dr Med Vet, PD, Dipl ECVS
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引用次数: 21

摘要

目前,角状肢体畸形(ALD)的治疗方法正在发生变化。虽然几年前的目标是早期发现和早期治疗,但最近的趋势更倾向于选择性治疗。未成熟马驹前体软骨不完全骨化,最好在腕骨和跗骨区识别,尽早用夹板治疗,以促进均匀轴向载荷下的骨化。患有干骺端不对称生长但骨化正常的小马驹通常要观察几个月,以便自己纠正。在严重的情况下,即畸形大于12°的马驹,也建议早期治疗。马驹患掌指骨/跖指骨区域内翻畸形应在1月龄前治疗。造成这种情况的原因是在大约3个月大的时候身体会过早闭合,在严重的情况下,近端指骨会出现相对的外翻畸形。治疗技术包括生长加速、暂时性单侧生长迟缓及其组合。半周骨膜横断剥脱术(HCPTS)的积极作用近年来受到质疑,但同时可以借助分子生物学技术建立纠正机制的途径。事实上,为反驳HCPTS效应而进行的实验有助于澄清其机制。简而言之:短干骺端附近的手术损伤会上调印度对冲猪(Ihh),它们通过传入血管到达骨骺,在那里它们上调甲状旁腺激素(PTH),并加速局部骨骺生长。随着途径的清除,这项技术重新获得了它以前的部分人气。生长迟缓可以通过几种外科技术来实现,这些技术可以暂时桥接骨较长一侧的物理,直到较短一侧赶上来。这种类型的管理被认为是对抗近端指骨外翻畸形的最新技术。一旦肢体伸直,植入物就会被移除。在双侧畸形中,可能需要在另一个肢体之前移除其中一个肢体的植入物。如果等到另一条腿也伸直了,那么更快矫正的那条可能已经矫枉过正了。最近,桡骨体外冲击波治疗已被引入,以无创的方式实现暂时的生长迟缓,效果明显良好。一旦骨骺闭合,角状肢体畸形就不能再通过生长调节来矫正。唯一可行的方法是一种类型的矫正截骨术或骨切除术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment of Angular Limb Deformities in Foals

Presently the approach to the treatment of angular limb deformities (ALD) is changing. While several years ago early recognition and early treatment was the aim, the recent trend goes more toward a selective approach. Immature foals with incomplete ossification of the precursor cartilage, best identified in the carpal and tarsal region are treated as early as possible with splints to facilitate ossification under even axial loads. Foals suffering from metaphyseal asymmetric growth but normal ossification are frequently observed for several months to allow to correct by themselves. In severe cases, meaning foals with deformities of greater than 12°, early treatment is proposed as well. Foals suffering from varus deformities of the metacarpophalangeal/metatarsophalangeal region should be treated before 1 month of age. The reason for this is the early closure of the physis at the approximate age of 3 months and in severe cases the development of an opposing valgus deformity within the proximal phalanx. Treatment techniques include growth acceleration, temporary unilateral growth retardation, and a combination thereof. The positive effect of hemicircumferential periosteal transection and stripping (HCPTS) was recently questioned, but in the mean time the pathway of the corrective mechanisms could be established with the help of molecular biology techniques. As a matter of fact, the experiments conducted to disprove the effect of HCPTS helped to clear up the mechanism. In a few words: the surgical insult near the shorter metaphyseal region upregulates Indian Hedge Hog (Ihh), which reach the physis via afferent blood vessels where they upregulate parathyroid hormones (PTH) and they accelerate the physeal growth locally. With the pathway cleared up, this technique regains part of its former popularity. Growth retardation can be achieved by several surgical techniques, which temporarily bridge the physis on the longer side of the bone until the shorter side has caught up. This type of management is proposed as state of the art in opposing valgus deformities of the proximal phalanx. Once the limb is straight the implants are removed. In bilateral deformities the implants in one limb may have to be removed before the other one. By waiting until the second limb is straight as well, the faster correcting one may have already overcorrected. Recently, radial extracorporal shock wave therapy has been introduced with apparently good results, to achieve a temporary growth retardation in a noninvasive manner. Once the physis is closed, angular limb deformities cannot be corrected any more through growth modulation. The only possible way is one type of corrective osteotomy or ostectomy.

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