泰国自闭症谱系障碍儿童CYP2D6和HLA-B*15:02的分子遗传分析:对药物遗传学检测和药物治疗优化的意义

Advances in genomics and genetics Pub Date : 2013-01-01 DOI:10.14456/TJG.2013.122

P. Suwannarat, M. Chamnanphon, Nattawat Ngamsamut, Ananya Sinrachatanant, Bhunnada Chamkrachchangpada, Teerarat Tan-kam, A. Puangpetch, C. Sukasem, P. Limsila

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引用次数: 5

摘要

CYP2D6和HLA-B的遗传多态性与包括自闭症谱系障碍(ASD)在内的各种抗精神病药物的疗效和毒性变化有关。本研究的目的是通过芯片技术对79名泰国ASD患者和154名非ASD患者的CYP2D6等位基因频率以及292名泰国ASD患者和627名非ASD患者的HLA-B*15:02等位基因频率进行调查和比较。CYP2D6*10、*1和*2等位基因在ASD组的最常见频率分别为54.43%(86/158)、22.78%(36/158)和11.39%(18/158)，非ASD组的最常见频率分别为44.18%(138/308)、26.30%(81/308)和7.47%(23/308)。HLA-B*15:02在ASD和非ASD中的表达频率分别为14.72%(43/292)和14.19%

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Molecular genetic analysis of CYP2D6 and HLA-B*15:02 in Thai autistic spectrum disorder children: Implication for pharmacogenetics testing and optimization of drug treatments

Genetic polymorphisms of CYP2D6 and HLA-B have been associated with efficacy and toxicity variation of various antipsychotic drugs including those for autistic spectrum disorders (ASD). The objective of this study is to investigate and compare allele frequency of CYP2D6 between 79 Thai ASD patients and 154 non-ASD by using microarray technique, and of HLA-B*15:02 between 292 Thai ASDs patients and 627 non-ASDs by using PCRSSOP based method. The most common allele frequency of CYP2D6*10, *1 and *2 in ASD group were 54.43% (86/158), 22.78% (36/158) and 11.39% (18/158), respectively, and nonASD were 44.18% (138/308), 26.30% (81/308) and 7.47% (23/308), respectively. The frequencies of HLA-B*15:02 in ASD and nonASD were 14.72% (43/292) and 14.19%

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Advances in genomics and genetics

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